Reactome | SUMO1-K132,K289-NR1H4 [nucleoplasm]

SUMO1-K132,K289-NR1H4 [nucleoplasm]

Stable Identifier

R-HSA-4755487

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bile acid receptor, NR1H4_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of NR1H4 with SUMO1 (Homo sapiens)
        
        2SUMO1:NR1H4:chenodeoxycholate [nucleoplasm] (Homo sapiens)
        
        SUMO1-K132,K289-NR1H4 [nucleoplasm] (Homo sapiens)

General

Lysine-289 in NR1H4-1 corresponds to lysine-277 in NR1H4-2.

External Reference Information

External Reference

UniProt:Q96RI1-2 NR1H4

Gene Names

NR1H4, BAR, FXR, HRR1, RIP14

Other Identifiers

0002470170

11756222_a_at

1554375_a_at

16755671

1OSH

1OSK

206340_at

3428224

3428226

3428228

3428229

3428230

3428231

3428237

3428242

3428253

3428255

3428256

3428257

3428258

3428262

3428263

3428264

3428265

38519_at

3BEJ

3DCT

3DCU

3FLI

3FXV

3GD2

3HC5

3HC6

3L1B

3OKH

3OKI

3OLF

3OMK

3OMM

3OOF

3OOK

3P88

3P89

3RUT

3RUU

3RVF

47699

4OIV

4QE6

4QE8

4WVD

5IAW

5ICK

5Q0I

5Q0J

5Q0K

5Q0L

5Q0M

5Q0N

5Q0O

5Q0P

5Q0Q

5Q0R

5Q0S

5Q0T

5Q0U

5Q0V

5Q0W

5Q0X

5Q0Y

5Q0Z

5Q10

5Q11

5Q12

5Q13

5Q14

5Q15

5Q16

5Q17

5Q18

5Q19

5Q1A

5Q1B

5Q1C

5Q1D

5Q1E

5Q1F

5Q1G

5Q1H

5Q1I

5WZX

5Y1J

5Y44

5Y49

5YXB

5YXD

5YXJ

5YXL

5Z12

6A5W

6A5X

6A5Y

6A5Z

6A60

7957835

9971

A_14_P109817

A_14_P137520

A_23_P25396

AAB08107

AAI30574

AAI44185

AAK60271

AAM53550

AAM53551

AB307699

AC010200

ADZ17382

AF384555

AF478445

AF478446

AK296612

B6ZGS9

BAH02290

BAH12398

BC130573

BC144183

BC144184

CCDS55873

CCDS55874

CCDS55875

CCDS55876

CCDS9078

CH471054

EAW97638

EAW97639

EAW97640

ENSG00000012504

ENSP00000188403

ENSP00000376712

ENSP00000447149

ENSP00000448506

ENSP00000448978

ENSP00000496908

ENST00000188403

ENST00000188403.7

ENST00000392986

ENST00000548884

ENST00000548884.5

ENST00000549996

ENST00000549996.5

ENST00000551379

ENST00000551379.5

ENST00000648861

ENST00000648861.1

EntrezGene:9971

EntrezGene:NR1H4

F1DAL1

F8W1M1

F8W656

g4826979_3p_at

G8JLB0

GE59358

GO:0000122

GO:0000228

GO:0000790

GO:0000976

GO:0000977

GO:0000980

GO:0000981

GO:0001080

GO:0001228

GO:0001678

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0003707

GO:0003713

GO:0003714

GO:0004879

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005719

GO:0006355

GO:0006357

GO:0006367

GO:0006464

GO:0006520

GO:0006629

GO:0006810

GO:0006950

GO:0006954

GO:0007043

GO:0007165

GO:0007219

GO:0007267

GO:0007275

GO:0008134

GO:0008150

GO:0008206

GO:0008219

GO:0008270

GO:0008289

GO:0009058

GO:0010804

GO:0010988

GO:0015031

GO:0015721

GO:0016922

GO:0022607

GO:0030154

GO:0030374

GO:0030522

GO:0032052

GO:0032088

GO:0032689

GO:0032692

GO:0032703

GO:0032715

GO:0032720

GO:0032991

GO:0034142

GO:0034162

GO:0034255

GO:0034330

GO:0034641

GO:0034971

GO:0035356

GO:0035774

GO:0038023

GO:0038181

GO:0038183

GO:0038185

GO:0042592

GO:0042593

GO:0042632

GO:0042742

GO:0043066

GO:0043124

GO:0043167

GO:0043226

GO:0043401

GO:0043565

GO:0044281

GO:0045087

GO:0045944

GO:0046628

GO:0046872

GO:0046965

GO:0048856

GO:0050728

GO:0051276

GO:0055088

GO:0055089

GO:0061178

GO:0070328

GO:0070857

GO:0070858

GO:0071222

GO:0071398

GO:0071417

GO:0071638

GO:0071941

GO:0072615

GO:0090181

GO:0090575

GO:1902122

GO:1902714

GO:1904179

GO:1904468

GO:1905695

GO:2000213

GO:2001250

HGNC:7967

HPA047699

HQ709175

Hs2.171683.2.S1_3p_s_at

ILMN_1708391

ILMN_1749335

IPR000536

IPR001628

IPR001723

IPR001728

IPR013088

IPR035500

MIM:603826

MIM:617049

NM_001206977

NM_001206978

NM_001206979

NM_001206992

NM_001206993

NM_005123

NP_001193906

NP_001193907

NP_001193908

NP_001193921

NP_001193922

NP_005114

NR1H4

NR1H4-201

NR1H4-203

NR1H4-206

NR1H4-207

NR1H4-209

NR1H4-210

NR_135146

PF00104

PF00105

PH_hs_0022500

PR00047

PR00398

PR00546

SM00399

SM00430

TC12000778.hg

U68233

U68233_at

UPI000002AFBD

UPI000006E701

UPI000006EFC9

UPI000013050E

UPI00020CE2BE

XM_011539040

XM_011539041

XP_011537342

XP_011537343

Participant Of

hasComponent

2SUMO1:NR1H4:chenodeoxycholate [nucleoplasm]

Other forms of this molecule

NR1H4-2 [nucleoplasm]

Inferred To

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Caenorhabditis elegans)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Canis familiaris)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Danio rerio)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Gallus gallus)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Mus musculus)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Rattus norvegicus)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Sus scrofa)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Xenopus tropicalis)

Homologues of SUMO1-K132,K289-NR1H4 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 289 and 97

Coordinate

289

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

Inter-chain Crosslink via sumoylated lysine at 132 and 97

Coordinate

132

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001193907.1, NP_001193921.1, NP_001193922.1, NP_001193908.1, XP_011537342.1, NP_005114.1, NP_001193906.1

ZINC - World Drugs

NR1H4_HUMAN

OpenTargets

ENSG00000012504

ZINC - FDA approved

NR1H4_HUMAN

ZINC - Substances

NR1H4_HUMAN

ZINC - Biogenic

NR1H4_HUMAN

ZINC target

Q96RI1

PRO

Q96RI1

PDB

5Q0U, 4QE6, 3P88, 5WZX, 5YXJ, 6A5W, 4OIV, 5Q15, 3OMM, 5Q0N, 5Y44, 5Q1G, 5Q19, 3OOK, 3DCU, 5Q12, 5Q0Y, 6A5Z, 3BEJ, 3RUT, 5Q0R, 5Q1C, 3HC5, 5Q18, 3L1B, 5Q14, 5Q0M, 5YXD, 5Q0T, 5Q1F, 1OSK, 5Q1I, 3RUU, 5Q11, 3HC6, 6A5Y, 5Q1B, 3OLF, 5ICK, 5Q0Q, 5Q0X, 5Q0J, 5Q0L, 5Q17, 3RVF, 5Q1E, 6HL1, 5Z12, 5Q0S, 5Q13, 5Q0P, 5Q1H, 3GD2, 5YXB, 5Q1A, 5YXL, 5Q10, 5Q0I, 5Q0W, 6A5X, 3FLI, 3OKH, 3P89, 5Y49, 5Q16, 3DCT, 5Y1J, 5Q1D, 5Q0K, 5Q0V, 4QE8, 6HL0, 4WVD, 5IAW, 1OSH, 5Q0Z, 3OOF, 5Q0O, 3OMK, 3FXV, 6A60, 3OKI

ZINC - Investigational

NR1H4_HUMAN

ZINC - Metabolites

NR1H4_HUMAN

GeneCards

Q96RI1

Orphanet

21199

ZINC - Predictions - Purchasable

NR1H4_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.633	5
UniProt:Q15788 NCOA1	3	NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) SUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 [nucleoplasm] (R-HSA-442496)	0.558	4
UniProt:FGF19 ENSG00000162344			0.527	2
IntAct:EBI-11173936 P2			0.524	4
IntAct:EBI-11173957 P4			0.524	4
IntAct:EBI-11173879 P1			0.524	4
IntAct:EBI-11173918 IR1			0.524	2