Reactome | SUMO1-K132,K289-NR1H4 [nucleoplasm]

SUMO1-K132,K289-NR1H4 [nucleoplasm]

Stable Identifier

R-HSA-4755487

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bile acid receptor, NR1H4_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of NR1H4 with SUMO1 (Homo sapiens)
        
        monoSUMO1-NR1H4:chenodeoxycholate [nucleoplasm] (Homo sapiens)
        
        SUMO1-K132,K289-NR1H4 [nucleoplasm] (Homo sapiens)

General

Lysine-289 in NR1H4-1 corresponds to lysine-277 in NR1H4-2.

External Reference Information

External Reference

UniProt:Q96RI1-2 NR1H4

Gene Names

NR1H4, BAR, FXR, HRR1, RIP14

Other Identifiers

11756222_a_at

1554375_PM_a_at

1554375_a_at

16755671

206340_PM_at

206340_at

3428224

3428226

3428228

3428229

3428230

3428231

3428237

3428242

3428253

3428255

3428256

3428257

3428258

3428262

3428263

3428264

3428265

38519_at

7957835

9971

A_14_P109817

A_14_P137520

A_23_P25396

GE59358

GO:0000122

GO:0000785

GO:0000791

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001080

GO:0001221

GO:0001228

GO:0001678

GO:0002376

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006520

GO:0006629

GO:0006954

GO:0007043

GO:0007219

GO:0008206

GO:0008270

GO:0008289

GO:0010804

GO:0010903

GO:0010988

GO:0012501

GO:0016922

GO:0023052

GO:0030154

GO:0030522

GO:0032052

GO:0032689

GO:0032692

GO:0032703

GO:0032715

GO:0032720

GO:0032740

GO:0034162

GO:0034255

GO:0034330

GO:0035356

GO:0035774

GO:0038181

GO:0038183

GO:0038185

GO:0042593

GO:0042632

GO:0042742

GO:0043066

GO:0043124

GO:0043226

GO:0043235

GO:0043565

GO:0045087

GO:0045893

GO:0045944

GO:0046628

GO:0046872

GO:0046965

GO:0048856

GO:0050728

GO:0055089

GO:0060089

GO:0061178

GO:0070328

GO:0070857

GO:0071222

GO:0071398

GO:0071417

GO:0071638

GO:0071941

GO:0090181

GO:0098542

GO:0140110

GO:1902122

GO:1903413

GO:1904179

GO:1905695

GO:2000213

GO:2001250

HMNXSV003015333

HMNXSV003020171

HMNXSV003039909

Hs2.171683.2.S1_3p_s_at

ILMN_1708391

PH_hs_0022500

TC12000778.hg

U68233_at

g4826979_3p_at

Participates

as a component of

monoSUMO1-NR1H4:chenodeoxycholate [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NR1H4-2 [nucleoplasm]

Inferred To

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Mus musculus)

SUMO1-K132,K289-NR1H4 [nucleoplasm] (Rattus norvegicus)

nr1h4 [nucleoplasm] (Danio rerio)

nr1h4 [nucleoplasm] (Xenopus tropicalis)

FXR [nucleoplasm] (Gallus gallus)

NR1H4 [nucleoplasm] (Bos taurus)

NR1H4 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 289

Coordinate

289

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 132

Coordinate

132

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001193906.1, NP_001193907.1, NP_005114.1, XP_011537342.1, NP_001193922.1, NP_001193921.1, NP_001193908.1

ZINC - World Drugs

NR1H4_HUMAN

Guide to Pharmacology - Targets

603

OpenTargets

ENSG00000012504

ZINC - FDA approved

NR1H4_HUMAN

ZINC - Substances

NR1H4_HUMAN

ZINC - Biogenic

NR1H4_HUMAN

ZINC target

Q96RI1

PRO

Q96RI1

PDB

5Q0K, 7VUE, 4QE8, 5Q0T, 3OOF, 5Y44, 5Q0I, 5Q14, 1OSH, 5Q1E, 5Q0Z, 3HC5, 6A5Z, 5Q15, 3OLF, 5Q12, 5Q18, 5WZX, 5Q1D, 5Q16, 5Q0J, 5Q10, 3P88, 5Q1H, 3DCU, 8HD3, 5YXL, 5Q17, 5Q0M, 5Q1G, 6A5W, 3OMM, 3HC6, 3L1B, 7TRB, 3RUT, 4WVD, 5Q1I, 3FLI, 5ICK, 4OIV, 6A60, 3RVF, 5Q1F, 7D42, 3P89, 5Q1C, 5Q0R, 5Q0Y, 3DCT, 5Q19, 5Q0P, 5Q0U, 5Q0N, 3OKI, 6A5X, 5YXJ, 5Q1B, 3GD2, 5Q0W, 3OMK, 5Q0L, 5Q0X, 3RUU, 5YXD, 6HL1, 3FXV, 5Q0Q, 5Q0S, 5Q1A, 5Q13, 3OOK, 8HBM, 5Y1J, 3BEJ, 5YXB, 5Q0V, 5IAW, 5Z12, 6HL0, 5Q11, 3OKH, 5Y49, 6A5Y, 6ITM, 5Q0O

ZINC - Investigational

NR1H4_HUMAN

ZINC - Metabolites

NR1H4_HUMAN

GeneCards

Q96RI1

HPA

ENSG00000012504-NR1H4

Ensembl

ENST00000188403, ENSP00000447149, ENSP00000448506, ENST00000648861, ENST00000551379, ENSP00000448978, ENST00000392986, ENSP00000188403, ENSP00000496908, ENSP00000376712, ENSG00000012504, ENST00000549996, ENST00000548884

Pharos - Targets

Q96RI1

Orphanet

21199

ZINC - Predictions - Purchasable

NR1H4_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.633	5
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.558	4
UniProt:FGF19 ENSG00000162344			0.527	2
UniProt:O75151 PHF2	1	PHF2 [nucleoplasm] (R-HSA-5423093)	0.525	2
IntAct:EBI-11173936 P2			0.524	4
IntAct:EBI-11173957 P4			0.524	4
IntAct:EBI-11173879 P1			0.524	4
IntAct:EBI-11173918 IR1			0.524	2