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SUMO1-K132,K289-NR1H4 [nucleoplasm]
Stable Identifier
R-HSA-4755487
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bile acid receptor, NR1H4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of NR1H4 with SUMO1 (Homo sapiens)
2SUMO1:NR1H4:chenodeoxycholate [nucleoplasm] (Homo sapiens)
SUMO1-K132,K289-NR1H4 [nucleoplasm] (Homo sapiens)
General
Lysine-289 in NR1H4-1 corresponds to lysine-277 in NR1H4-2.
External Reference Information
External Reference
UniProt:Q96RI1-2 NR1H4
Gene Names
NR1H4, BAR, FXR, HRR1, RIP14
Other Identifiers
0002470170
11756222_a_at
1554375_a_at
16755671
206340_at
3428224
3428226
3428228
3428229
3428230
3428231
3428237
3428242
3428253
3428255
3428256
3428257
3428258
3428262
3428263
3428264
3428265
38519_at
7957835
9971
A_14_P109817
A_14_P137520
A_23_P25396
GE59358
GO:0000122
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001080
GO:0001228
GO:0001678
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005719
GO:0006355
GO:0006357
GO:0006367
GO:0006464
GO:0006520
GO:0006629
GO:0006810
GO:0006950
GO:0006954
GO:0007043
GO:0007165
GO:0007219
GO:0007267
GO:0008134
GO:0008150
GO:0008206
GO:0008219
GO:0008270
GO:0008289
GO:0009058
GO:0010804
GO:0010903
GO:0010988
GO:0015031
GO:0015721
GO:0016922
GO:0022607
GO:0030154
GO:0030522
GO:0032052
GO:0032088
GO:0032620
GO:0032689
GO:0032692
GO:0032703
GO:0032715
GO:0032720
GO:0032991
GO:0034142
GO:0034162
GO:0034255
GO:0034330
GO:0034641
GO:0034971
GO:0035356
GO:0035774
GO:0038023
GO:0038181
GO:0038183
GO:0038185
GO:0042025
GO:0042592
GO:0042593
GO:0042632
GO:0042742
GO:0043066
GO:0043124
GO:0043167
GO:0043226
GO:0043235
GO:0043565
GO:0044281
GO:0045087
GO:0045893
GO:0045944
GO:0046628
GO:0046872
GO:0046965
GO:0048856
GO:0050728
GO:0051276
GO:0055088
GO:0055089
GO:0061178
GO:0070328
GO:0070857
GO:0071222
GO:0071398
GO:0071417
GO:0071638
GO:0071941
GO:0090181
GO:0090575
GO:1902122
GO:1903413
GO:1904179
GO:1904468
GO:1905695
GO:2000213
GO:2001250
Hs2.171683.2.S1_3p_s_at
ILMN_1708391
ILMN_1749335
PH_hs_0022500
TC12000778.hg
U68233_at
g4826979_3p_at
Participant Of
hasComponent
2SUMO1:NR1H4:chenodeoxycholate [nucleoplasm]
Other forms of this molecule
NR1H4-2 [nucleoplasm]
Inferred To
SUMO1-K132,K289-NR1H4 [nucleoplasm] (Gallus gallus)
SUMO1-K132,K289-NR1H4 [nucleoplasm] (Sus scrofa)
SUMO1-K132,K289-NR1H4 [nucleoplasm] (Xenopus tropicalis)
Nr1h4 [nucleoplasm] (Mus musculus)
Nr1h4 [nucleoplasm] (Rattus norvegicus)
nhr-8 [nucleoplasm] (Caenorhabditis elegans)
Homologues of SUMO1-K132,K289-NR1H4 [nucleoplasm] (Caenorhabditis elegans)
nr1h4 [nucleoplasm] (Danio rerio)
daf-12 [nucleoplasm] (Caenorhabditis elegans)
nhr-48 [nucleoplasm] (Caenorhabditis elegans)
NR1H4 [nucleoplasm] (Canis familiaris)
unc-55 [nucleoplasm] (Caenorhabditis elegans)
Modified Residues
Name
Inter-chain Crosslink via sumoylated lysine at 289 and 97
Coordinate
289
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
Inter-chain Crosslink via sumoylated lysine at 132 and 97
Coordinate
132
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_005114.1
,
NP_001193907.1
,
XP_011537342.1
,
NP_001193921.1
,
NP_001193908.1
,
NP_001193922.1
,
NP_001193906.1
ZINC - World Drugs
NR1H4_HUMAN
OpenTargets
ENSG00000012504
ZINC - FDA approved
NR1H4_HUMAN
ZINC - Substances
NR1H4_HUMAN
ZINC - Biogenic
NR1H4_HUMAN
ZINC target
Q96RI1
PRO
Q96RI1
PDB
5Q0N
,
5Z12
,
5YXB
,
3DCT
,
5Q1B
,
3P88
,
6A5W
,
5Q0Y
,
6HL0
,
3HC6
,
5Q0S
,
5Q1F
,
5Q19
,
4QE8
,
6A5Z
,
5Q13
,
3OOF
,
5Q0U
,
5Q11
,
1OSK
,
5Q17
,
3L1B
,
6A5Y
,
5Y44
,
5Q0X
,
5Q1E
,
5Q0L
,
5Q14
,
5Q1A
,
5YXD
,
4WVD
,
5Q0Q
,
3FXV
,
5Q0M
,
3OKH
,
5Q0T
,
5Q1G
,
5ICK
,
3P89
,
5YXL
,
5Y49
,
3GD2
,
5Q1I
,
5Q0W
,
1OSH
,
5Q10
,
3OMM
,
5Q0K
,
5Q0I
,
5Q16
,
3OOK
,
5Q1D
,
5YXJ
,
3FLI
,
5Q0P
,
3OKI
,
3HC5
,
3OLF
,
5Y1J
,
5IAW
,
3OMK
,
3DCU
,
5Q0Z
,
6HL1
,
5Q0V
,
4OIV
,
5Q1H
,
5Q1C
,
5Q0O
,
3RUU
,
6A60
,
3RVF
,
6ITM
,
5Q0R
,
3RUT
,
3BEJ
,
5Q12
,
4QE6
,
5Q18
,
5Q0J
,
5Q15
,
5WZX
,
6A5X
ZINC - Investigational
NR1H4_HUMAN
ZINC - Metabolites
NR1H4_HUMAN
HPA
ENSG00000012504-NR1H4
GeneCards
Q96RI1
Ensembl
ENSP00000376712
,
ENST00000392986
,
ENSP00000496908
,
ENSP00000188403
,
ENSG00000012504
,
ENST00000188403
,
ENST00000551379
,
ENSP00000448978
,
ENSP00000447149
,
ENSP00000448506
,
ENST00000648861
,
ENST00000548884
,
ENST00000549996
ZINC - Predictions - Purchasable
NR1H4_HUMAN
Orphanet
21199
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.633
5
UniProt:Q15788 NCOA1
3
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
SUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.558
4
UniProt:FGF19 ENSG00000162344
0.527
2
IntAct:EBI-11173936 P2
0.524
4
IntAct:EBI-11173957 P4
0.524
4
IntAct:EBI-11173879 P1
0.524
4
IntAct:EBI-11173918 IR1
0.524
2
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