SUMOylation of NFKB2 with SUMO1

Stable Identifier
R-HSA-4755479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SUMOylation of NFKB2 with SUMO1
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Unprocessed NFKB2 p100 is SUMOylated with SUMO1 at lysine-90, lysine-298, lysine-689, and lysine-863 (Vatsyayan et al. 2008). SUMOylation of p100 is required for phosphorylation of p100 prior to processing to yield p52. Blockage of SUMOylation consequently interferes with import of NFKB2 p52 into the nucleus.
Literature References
PubMed ID Title Journal Year
18617892 SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing

Vatsyayan, J, Qing, G, Xiao, G, Hu, J

EMBO Rep. 2008
Participants
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Output
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Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytosol]

Physical Entity
SUMO1:C93-UBE2I [cytosol] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of NFKB2 with SUMO1 (Bos taurus)
SUMOylation of NFKB2 with SUMO1 (Danio rerio)
SUMOylation of NFKB2 with SUMO1 (Gallus gallus)
SUMOylation of NFKB2 with SUMO1 (Mus musculus)
SUMOylation of NFKB2 with SUMO1 (Rattus norvegicus)
SUMOylation of NFKB2 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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