Reactome | monoSUMO1-K270-NR5A2-2 [nucleoplasm]

monoSUMO1-K270-NR5A2-2 [nucleoplasm]

Stable Identifier

R-HSA-4755447

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor subfamily 5 group A member 2, NR5A2_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)
        
        monoSUMO1-NR5A2:cis-bicyclo(3.3.0)oct-2-ene [nucleoplasm] (Homo sapiens)
        
        monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Homo sapiens)

General

Lysine-270 in the long isoform (isoform 2) corresponds to lysine-224 in the shorter isoform (isoform 1).

External Reference Information

External Reference

UniProt:O00482-2 NR5A2

Gene Names

NR5A2, B1F, CPF, FTF

Other Identifiers

11727749_a_at

11727750_a_at

11727751_a_at

11738122_a_at

16675638

208337_PM_s_at

208337_s_at

208343_PM_s_at

208343_s_at

210174_PM_at

210174_at

2374138

2374139

2374157

2374158

2374162

2374163

2374165

2374167

2374198

2374200

2374201

2374213

2374214

2374215

2494

35865_at

59241_at

7908597

A_14_P109851

A_14_P126842

A_14_P202308

A_23_P161004

A_23_P993

A_24_P920090

A_33_P3389728

GE53511

GE81325

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0004879

GO:0005515

GO:0005543

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0008206

GO:0008270

GO:0008289

GO:0009755

GO:0009792

GO:0009888

GO:0023052

GO:0030154

GO:0030522

GO:0042127

GO:0042592

GO:0042632

GO:0043226

GO:0043565

GO:0045070

GO:0045893

GO:0045944

GO:0046872

GO:0048856

GO:0060089

GO:0061113

GO:0090425

GO:0090575

GO:0097720

GO:0140110

GO:1990830

GO:1990837

HMNXSV003012483

Hs.183123.1.S4_3p_at

ILMN_1688932

ILMN_1811303

ILMN_2366654

PH_hs_0010803

TC01001645.hg

TC01004937.hg

U93553_at

g4504342_3p_a_at

g5002241_3p_a_at

Participates

as a component of

monoSUMO1-NR5A2:cis-bicyclo(3.3.0)oct-2-ene [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NR5A2-2 [nucleoplasm]

Inferred To

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Bos taurus)

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Danio rerio)

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Mus musculus)

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Rattus norvegicus)

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Sus scrofa)

monoSUMO1-K270-NR5A2-2 [nucleoplasm] (Xenopus tropicalis)

NR5A2 [nucleoplasm] (Gallus gallus)

nhr-25 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 270

Coordinate

270

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011507684.1, NP_003813.1, NP_001263393.1, NP_995582.1, XP_005245119.1

Guide to Pharmacology - Targets

633

OpenTargets

ENSG00000116833

ZINC - Substances

NR5A2_HUMAN

ZINC target

O00482

PRO

O00482

PDB

5UNJ, 4PLD, 4IS8, 2A66, 6OR1, 4DOS, 1YOK, 5SYZ, 6VC2, 7JYD, 5L11, 1ZDU, 3PLZ, 6OQX, 4RWV, 4ONI, 4PLE, 7JYE, 7TT8, 4DOR, 3TX7, 5L0M, 6VIF, 1YUC, 6OQY, 8F8M

GeneCards

O00482

HPA

ENSG00000116833-NR5A2

Ensembl

ENST00000367362, ENSP00000236914, ENSG00000116833, ENSP00000439116, ENSP00000356331, ENST00000544748, ENST00000236914

Pharos - Targets

O00482

ZINC - Predictions - Purchasable

NR5A2_HUMAN

HMDB Protein

HMDBP12658

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.547	2