SUMOylation of NR1H4 with SUMO1

Stable Identifier
R-HSA-4755419
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of NR1H4 with SUMO1
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NR1H4 (FXR, Bile Acid Receptor) is SUMOylated with SUMO1 at lysine-132 and lysine-289 (lysine-122 and lysine-275 of isoform 4, UniProt Q96RI1-2) (Vavassori et al. 2009, Balasubramaniyan et al. 2013). SUMOylation appears to be enhanced when NR1H4 binds ligands (Vavassori et al. 2009). SUMOylated NR1H4 transrepresses genes involved in inflammation (Vavassori et al. 2009) and inhibits ligand-induced activation of FXR targets: bile salt export pump (BSEP) and small heterodimer partner (SHP) (Balasubramaniya et al. 2013).
Literature References
PubMed ID Title Journal Year
23546875 SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes

Balasubramaniyan, N, Luo, Y, Sun, AQ, Suchy, FJ

J. Biol. Chem. 2013
19864602 The bile acid receptor FXR is a modulator of intestinal innate immunity

Vavassori, P, Mencarelli, A, Renga, B, Distrutti, E, Fiorucci, S

J. Immunol. 2009
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Orthologous Events
SUMOylation of NR1H4 with SUMO1 (Bos taurus)
SUMOylation of NR1H4 with SUMO1 (Caenorhabditis elegans)
SUMOylation of NR1H4 with SUMO1 (Danio rerio)
SUMOylation of NR1H4 with SUMO1 (Gallus gallus)
SUMOylation of NR1H4 with SUMO1 (Mus musculus)
SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)
SUMOylation of NR1H4 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-06-11)
Created
May, B  (2013-10-25)
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