KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3

Stable Identifier
Reaction [transition]
Homo sapiens
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All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine epsilon-amine group and consequently JmjC containing demethylases are able to catalyse demethylateion of tri , di and monomethylated lysines. KDM3A (JHDM2A), KDM3B (JHDM2B), KDM7A (JHDM1D), PHF8 (JHDM1E) and PHF2 when complexed with ARID5B (Wen et al. 2010, Baba et al. 2011) are specific for mono or di-methylated lysine-10 on histone H3 (H3K9Me1/2) (Yamane et al. 2006, Kim et al. 2012, Horton et al. 2010, Huang et al. 2010, Loenarz et al. 2008, Feng et al. 2010, Fortschegger et al. 2010, Qi et al. 2010).
Literature References
PubMed ID Title Journal Year
20129925 Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation

Sha, B, Lee, MG, Li, J, Song, T, Wen, H, Lu, M, Shi, X, Kan, PY

J. Biol. Chem. 2010
20084082 Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

Xiang, Y, Zhu, Q, Li, X, Jing, N, Xu, L, Huang, C, Chen, CD, Zhang, K, Zhu, Z, Wang, Y, Zhang, T

Cell Res. 2010
19843542 PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

Cooper, CD, Klose, RJ, Coleman, ML, Ratcliffe, PJ, Schofield, CJ, Ge, W, Rose, NR, Loenarz, C

Hum. Mol. Genet. 2010
21532585 PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

Brown, M, Okada, M, Ohtake, F, Baba, A, Igarashi, K, Yokota, K, Ni, M, Imai, Y, Okuno, Y, Kanno, J, Meyer, CA, Kato, S

Nat. Cell Biol. 2011
22615488 KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia

Kee, HJ, Baek, HJ, Choe, N, Kim, DW, Pak, JH, Kim, JY, Kook, H, Oh, ST, Kook, H, Son, HJ, Seo, SB, Kim, KB, Chakravarti, D, Eom, GH, Hahn, Y

Mol. Cell. Biol. 2012
16603237 JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

Toumazou, C, Tsukada, Y, Yamane, K, Zhang, Y, Tempst, P, Wong, J, Erdjument-Bromage, H

Cell 2006
20208542 PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

Jenuwein, T, Feng, W, Ye, J, Yonezawa, M, Grummt, I

Nat. Struct. Mol. Biol. 2010
20023638 Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

Shi, Y, Zhang, X, Upadhyay, AK, Horton, JR, Cheng, X, Qi, HH

Nat. Struct. Mol. Biol. 2010
Catalyst Activity

histone demethylase activity of KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm]

Orthologous Events
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