HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3

Stable Identifier
R-HSA-4720446
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HDAC4 SUMOylates NR1H3 with SUMO2,3 (Ghisletti et al. 2007). SUMOylation is enhanced when NR1H3 binds specific oxysterols. SUMOylation causes NR1H3 to recruit the NCOR repressor and act as a transrepressor at promoters such as iNOS.

Literature References
PubMed ID Title Journal Year
17218271 Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

Ghisletti, S, Huang, W, Ogawa, S, Pascual, G, Lin, ME, Willson, TM, Rosenfeld, MG, Glass, CK

Mol. Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of HDAC4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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