Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
polySUMO2,3-NR1H3 [nucleoplasm]
Stable Identifier
R-HSA-4720441
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Oxysterols receptor LXR-alpha isoform 1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
SUMO2,3-NR1H3:hydroxysterol [nucleoplasm] (Homo sapiens)
polySUMO2,3-NR1H3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13133-1 NR1H3
Gene Names
NR1H3, LXRA
Other Identifiers
10062
11719393_a_at
16724485
203920_PM_at
203920_at
33106_at
3329686
3329689
3329690
3329691
3329692
3329693
3329694
3329695
3329696
3329697
3329699
3329700
3329701
3329702
3329703
3329705
3329707
3329708
3329711
3329713
3329714
3329715
3329716
3329717
3329718
3329725
512_at
7939751
A_14_P122332
A_23_P47135
A_33_P3237775
GE81543
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006954
GO:0008270
GO:0008289
GO:0009755
GO:0010745
GO:0010867
GO:0010875
GO:0010887
GO:0015485
GO:0016071
GO:0016192
GO:0022600
GO:0023052
GO:0030154
GO:0030522
GO:0031490
GO:0032369
GO:0032376
GO:0032411
GO:0032570
GO:0032810
GO:0034145
GO:0036151
GO:0042632
GO:0042752
GO:0042789
GO:0043031
GO:0043226
GO:0043235
GO:0043277
GO:0043565
GO:0044255
GO:0045723
GO:0045861
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046889
GO:0048550
GO:0050728
GO:0051006
GO:0051247
GO:0055088
GO:0055092
GO:0060089
GO:0060336
GO:0070328
GO:0071222
GO:0090188
GO:0090341
GO:0090575
GO:0098542
GO:0120163
GO:0140110
GO:1903573
HMNXSV003022469
ILMN_1814022
PH_hs_0033433
TC11000405.hg
U22662_at
g5031892_3p_at
Participates
as a component of
SUMO2,3-NR1H3:hydroxysterol [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NR1H3-1 [nucleoplasm]
Inferred To
NR1H3 [nucleoplasm]
(Bos taurus)
NR1H3 [nucleoplasm]
(Gallus gallus)
im:7141239 [nucleoplasm]
(Danio rerio)
EcR [nucleoplasm]
(Drosophila melanogaster)
Nr1h3 [nucleoplasm]
(Mus musculus)
Nr1h3 [nucleoplasm]
(Rattus norvegicus)
polySUMO2,3-NR1H3 [nucleoplasm]
(Canis familiaris)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
XP_006718175.1
,
XP_016872547.1
,
XP_006718179.1
,
NP_001123573.1
,
XP_005252763.1
,
XP_006718178.1
,
NP_001123574.1
,
NP_005684.2
,
XP_005252767.1
,
XP_006718176.1
,
XP_005252762.1
,
XP_005252770.1
,
XP_005252764.1
,
XP_005252766.1
,
XP_011518107.1
Guide to Pharmacology - Targets
602
OpenTargets
ENSG00000025434
ZINC - Substances
NR1H3_HUMAN
ZINC - Biogenic
NR1H3_HUMAN
ZINC target
Q13133
PRO
Q13133
PDB
5AVL
,
1UHL
,
3IPU
,
5HJS
,
3IPS
,
3IPQ
,
5AVI
ZINC - Metabolites
NR1H3_HUMAN
GeneCards
Q13133
HPA
ENSG00000025434-NR1H3
Ensembl
ENSG00000025434
,
ENST00000441012
,
ENST00000407404
,
ENSP00000385801
,
ENSP00000387946
,
ENSP00000384745
,
ENST00000405853
,
ENSP00000420656
,
ENSP00000378793
,
ENST00000467728
,
ENST00000395397
Pharos - Targets
Q13133
ZINC - Predictions - Purchasable
NR1H3_HUMAN
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48443 RXRG
1
RXRG [nucleoplasm]
(R-HSA-446170)
0.742
7
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.691
15
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.611
5
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.609
8
UniProt:O60869 EDF1
0.581
4
UniProt:P28702 RXRB
1
RXRB [nucleoplasm]
(R-HSA-446163)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.525
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text