Reactome | polySUMO2,3-NR1H3 [nucleoplasm]

polySUMO2,3-NR1H3 [nucleoplasm]

Stable Identifier

R-HSA-4720441

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Oxysterols receptor LXR-alpha isoform 1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13133-1 NR1H3

Gene Names

NR1H3, LXRA

Participates

as a component of

SUMO2,3-NR1H3:hydroxysterol [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NR1H3-1 [nucleoplasm]

Inferred To

NR1H3 [nucleoplasm] (Bos taurus)

NR1H3 [nucleoplasm] (Gallus gallus)

NR1H3 [nucleoplasm] (Sus scrofa)

nr1h3 [nucleoplasm] (Danio rerio)

EcR [nucleoplasm] (Drosophila melanogaster)

Nr1h3 [nucleoplasm] (Mus musculus)

Nr1h3 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_005252766.1, XP_047282150.1, XP_005252770.1, XP_005252767.1, XP_054223352.1, XP_054223353.1, XP_011518107.1, NP_005684.2, XP_005252764.1, XP_005252763.1, XP_005252762.1, XP_006718176.1, XP_006718179.1, XP_006718175.1, XP_006718178.1, XP_054223355.1, XP_054223350.1, XP_047282149.1, XP_054223357.1, XP_054223356.1, XP_024304066.1, XP_054223351.1, XP_047282151.1, XP_016872547.1, XP_047282154.1, XP_047282153.1, XP_047282156.1, XP_047282155.1, XP_047282157.1, XP_054223344.1, XP_054223345.1, NP_001123574.1, XP_054223346.1, XP_054223347.1, NP_001123573.1

Guide to Pharmacology - Targets

602

OpenTargets

ENSG00000025434

ENSEMBL

ENST00000441012, ENSG00000025434, ENSP00000378793, ENSP00000420656, ENST00000405853, ENST00000395397, ENSP00000384745, ENST00000467728, ENST00000407404, ENSP00000387946, ENSP00000385801

ZINC - Substances

NR1H3_HUMAN

ZINC - Biogenic

NR1H3_HUMAN

ZINC target

Q13133

PRO

Q13133

GlyGen

Q13133

PDB

1UHL, 5AVL, 3IPU, 5AVI, 3IPQ, 3IPS, 5HJS

ZINC - Metabolites

NR1H3_HUMAN

HPA

ENSG00000025434-NR1H3

GeneCards

NR1H3

Pharos - Targets

Q13133

ZINC - Predictions - Purchasable

NR1H3_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.742	7
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.691	15
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.666	4
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.642	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.611	5
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.609	8
UniProt:O60869 EDF1			0.581	4
UniProt:Q99750 MDFI			0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

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