PIAS2-2 (PIASx-alpha) SUMOylates THRA (alpha-1 isoform) with SUMO1 at lysine-283 and lysine-389 (Liu et al. 2012). (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.) SUMOylation by SUMO3 but not SUMO1 enhances induction of gene expression in response to the ligand triiodothyroxine.
Schultz, JJ, Liu, YY, Kogai, T, Mody, K, Brent, GA
SUMO transferase activity of PIAS2-2 [nucleoplasm]
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