PIAS2-2 SUMOylates THRA with SUMO1

Stable Identifier
R-HSA-4719447
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PIAS2-2 SUMOylates THRA with SUMO1
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PIAS2-2 (PIASx-alpha) SUMOylates THRA (alpha-1 isoform) with SUMO1 at lysine-283 and lysine-389 (Liu et al. 2012). (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.) SUMOylation by SUMO3 but not SUMO1 enhances induction of gene expression in response to the ligand triiodothyroxine.

Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Liu, YY, Kogai, T, Schultz, JJ, Mody, K, Brent, GA

J. Biol. Chem. 2012
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Catalyst Activity

SUMO transferase activity of PIAS2-2 [nucleoplasm]

Physical Entity
PIAS2-2 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)
PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)
PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)
PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-10-18)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-19)
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