PIAS2,3,4 SUMOylate RORA with SUMO1

Stable Identifier
R-HSA-4719436
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIAS2,3,4 SUMOylate RORA with SUMO1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS2-2 (PIASx-alpha), PIAS3, and PIAS4 SUMOylate RORA with SUMO1 at lysine-240 (Hwang et al. 2009). SUMOylation increases transcriptional activation by RORA.
Literature References
PubMed ID Title Journal Year
19041634 SUMOylation of RORalpha potentiates transcriptional activation function

Kim, KI, Park, JH, Yang, Y, Hwang, EJ, Baek, SH, Lee, JM, Lim, JS, Kim, JH, Jeong, J

Biochem. Biophys. Res. Commun. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of PIAS2-2,PIAS3,PIAS4 [nucleoplasm]

Physical Entity
PIAS2-2,PIAS3,PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Caenorhabditis elegans)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Sus scrofa)
Authored
May, B  (2013-10-18)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-19)
Cite Us!