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SUMO1-K240-RORA [nucleoplasm]
Stable Identifier
R-HSA-4719422
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor ROR-alpha, RORA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
SUMO1:RORA [nucleoplasm] (Homo sapiens)
SUMO1-K240-RORA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35398 RORA
Gene Names
RORA, NR1F1, RZRA
Chain
chain:1-523
Reference Genes
BioGPS Gene:6095 RORA
COSMIC (genes):RORA RORA
CTD Gene:6095 RORA
dbSNP Gene:6095 RORA
ENSEMBL:ENSG00000069667 RORA
HGNC:10258 RORA
KEGG Gene (Homo sapiens):6095 RORA
Monarch:6095 RORA
NCBI Gene:6095 RORA
OMIM:600825 RORA
UCSC:P35398 RORA
Reference Transcript
RefSeq:NM_134261.2 RORA
RefSeq:NM_002943.3 RORA
RefSeq:NM_134262.2 RORA
RefSeq:NM_134260.2 RORA
Other Identifiers
0001090400
0004060181
0006100619
0106860091
11725675_a_at
11725676_a_at
11726244_a_at
210426_x_at
210479_s_at
226682_at
235567_at
236266_at
240951_at
32899_s_at
3627417
3627419
3627421
3627423
3627424
3627425
3627426
3627427
3627428
3627429
3627430
3627431
3627433
3627434
3627435
3627437
3627440
3627441
3627449
3627463
3627465
3627507
3627508
3627530
3627637
3627638
56746_at
57712_at
6095
64643_at
7989365
82266_at
A_23_P26124
A_32_P7721
GE790105
GE81213
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001222
GO:0001223
GO:0001525
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005975
GO:0006355
GO:0006367
GO:0006629
GO:0006805
GO:0006809
GO:0006950
GO:0007165
GO:0007275
GO:0007623
GO:0008013
GO:0008134
GO:0008142
GO:0008150
GO:0008270
GO:0008283
GO:0008289
GO:0008589
GO:0009058
GO:0010575
GO:0010906
GO:0019218
GO:0019221
GO:0021702
GO:0021930
GO:0030154
GO:0030522
GO:0032922
GO:0034641
GO:0036315
GO:0042025
GO:0042592
GO:0042632
GO:0042692
GO:0042752
GO:0042753
GO:0043030
GO:0043124
GO:0043167
GO:0043226
GO:0043565
GO:0044281
GO:0045599
GO:0045893
GO:0045944
GO:0046068
GO:0046872
GO:0048511
GO:0048646
GO:0048856
GO:0050728
GO:0060850
GO:0070328
GO:0071347
GO:0071356
GO:0071456
GO:0072539
GO:0098531
Hs.134667.0.A1_3p_at
Hs.293968.0.A1_3p_at
Hs.37648.0.A1_3p_at
Hs.37648.1.A1_3p_at
ILMN_1665167
ILMN_1743536
ILMN_1805614
ILMN_1862909
ILMN_1867517
ILMN_1894610
ILMN_2322498
ILMN_2322499
PH_hs_0002958
PH_hs_0024015
PH_hs_0024472
TC15001507.hg
TC15002563.hg
U04898_at
g348240_3p_a_at
Participant Of
hasComponent
SUMO1:RORA [nucleoplasm]
Other forms of this molecule
SUMO2-K240-RORA [nucleoplasm]
RORA [nucleoplasm]
Inferred To
Rora [nucleoplasm] (Mus musculus)
Rora [nucleoplasm] (Rattus norvegicus)
bloc1s3 [nucleoplasm] (Xenopus tropicalis)
nhr-23 [nucleoplasm] (Caenorhabditis elegans)
RORA [nucleoplasm] (Bos taurus)
RORA [nucleoplasm] (Canis familiaris)
RORA [nucleoplasm] (Gallus gallus)
RORA [nucleoplasm] (Sus scrofa)
roraa [nucleoplasm] (Danio rerio)
Modified Residues
Name
Inter-chain Crosslink via sumoylated lysine at 240 and 97
Coordinate
240
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_002934.1
,
NP_599023.1
,
NP_599024.1
,
NP_599022.1
ZINC - World Drugs
RORA_HUMAN
OpenTargets
ENSG00000069667
ZINC - Substances
RORA_HUMAN
ZINC target
P35398
ZINC - Biogenic
RORA_HUMAN
PRO
P35398
PDB
1N83
,
1S0X
,
4S15
ZINC - Metabolites
RORA_HUMAN
GeneCards
P35398
HPA
ENSG00000069667-RORA
Ensembl
ENSP00000261523
,
ENST00000335670
,
ENST00000261523
,
ENSG00000069667
,
ENSP00000335087
ZINC - Predictions - Purchasable
RORA_HUMAN
Orphanet
24867
HMDB Protein
HMDBP02591
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14136 GFAP
3
GFAP [lysosomal membrane]
(R-HSA-9625195)
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.553
2
UniProt:P51843 NR0B1
0.508
2
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