polySUMO3-K283,K389-THRA-2 [nucleoplasm]

Stable Identifier
R-HSA-4719416
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Thyroid hormone receptor alpha, THA_HUMAN
Locations in the PathwayBrowser
Expand all
General

PIAS2-2 SUMOylates THRA (alpha-1 isoform, THRA-2 in UniProt) with SUMO3 at lysine-283 and lysine-389. (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.)

External Reference Information
External Reference
UniProt:P10827-2 THRA
Gene Names
THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2
Other Identifiers
0001570577
0006370692
11717773_a_at
11734119_a_at
11734120_x_at
11747680_a_at
11747681_x_at
11750897_a_at
11759126_a_at
11761993_a_at
1316_at
16833965
204100_at
214883_at
35846_at
3720696
3720697
3720698
3720702
3720703
3720705
3720706
3720707
3720709
3720710
3720713
3720714
3720715
3720716
3720717
3720718
3720719
3720720
3720721
3720722
3720723
3720724
3720725
3720727
3720729
4898680_3p_at
616_s_at
7067
8007008
86815_at
A_14_P108110
A_14_P130248
A_14_P200471
A_23_P207742
A_24_P262407
GE81253
GO:0000003
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001502
GO:0001503
GO:0002154
GO:0002155
GO:0002376
GO:0003013
GO:0003674
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006629
GO:0006950
GO:0007165
GO:0007611
GO:0008016
GO:0008050
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0009056
GO:0009058
GO:0009409
GO:0009755
GO:0009887
GO:0017025
GO:0017055
GO:0019904
GO:0022607
GO:0030154
GO:0030218
GO:0030522
GO:0030878
GO:0031490
GO:0033032
GO:0034641
GO:0042592
GO:0043167
GO:0043226
GO:0043565
GO:0044877
GO:0045892
GO:0045925
GO:0045944
GO:0046872
GO:0048856
GO:0050877
GO:0050994
GO:0060509
GO:0065003
GO:0070324
GO:0120162
GO:2000143
HMNXSV003009754
HMNXSV003017851
ILMN_1654613
ILMN_1661683
ILMN_1718182
M24748_cds2_s_at
M24899_at
PH_hs_0030854
TC17000488.hg
TC17002195.hg
TC17002196.hg
X55005_rna1_at
X55005mRNA_3p_s_at
g4507494_3p_s_at
Participates
as an output of
Other forms of this molecule
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
THRA-2 [nucleoplasm]
Inferred To
polySUMO3-K283,K389-THRA-2 [nucleoplasm] (Xenopus tropicalis)
thrab [nucleoplasm] (Danio rerio)
Eip75B [nucleoplasm] (Drosophila melanogaster)
Thra [nucleoplasm] (Mus musculus)
Thra [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (polySUMO3 [nucleoplasm]) at 283
Coordinate
283
Modification
polySUMO3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO3 [nucleoplasm]) at 389
Coordinate
389
Modification
polySUMO3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
588
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (2)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15648 MED1  1 0.591 4
 UniProt:O95971 CD160  1 0.556 3
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