SUMO3-K283,K389-THRA-2 [nucleoplasm]

Stable Identifier
R-HSA-4719416
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Thyroid hormone receptor alpha, THA_HUMAN
Locations in the PathwayBrowser
Expand all
General

PIAS2-2 SUMOylates THRA (alpha-1 isoform, THRA-2 in UniProt) with SUMO3 at lysine-283 and lysine-389. (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.)

External Reference Information
External Reference
UniProt:P10827-2 THRA
Gene Names
THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2
Other Identifiers
0001570577
0006370692
11717773_a_at
11734119_a_at
11734120_x_at
11747680_a_at
11747681_x_at
11750897_a_at
11759126_a_at
11761993_a_at
1316_at
16833965
1NAV
204100_at
214883_at
23349
2H77
2H79
35846_at
3720696
3720697
3720698
3720702
3720703
3720705
3720706
3720707
3720709
3720710
3720713
3720714
3720715
3720716
3720717
3720718
3720719
3720720
3720721
3720722
3720723
3720724
3720725
3720727
3720729
3HZF
3ILZ
3JZB
4898680_3p_at
4LNW
4LNX
616_s_at
7067
8007008
86815_at
9654
A_14_P108110
A_14_P130248
A_23_P207742
A_24_P262407
AAA35783
AAA52333
AAA61176
AAA66021
AAH00261
AAH02728
AAH08851
AAH35137
AAM77692
ADZ17370
AF522368
AK290530
BAF83219
BC000261
BC002728
BC008851
BC035137
CAA38749
CAA38899
CAA68539
CAB023349
CAB57886
CAG46713
CCDS11360
CCDS42316
CCDS58546
CH471152
CR541915
EAW60632
EAW60633
ENSG00000126351
ENSP00000264637
ENSP00000377679
ENSP00000395641
ENSP00000443972
ENSP00000463466
ENST00000264637
ENST00000264637.8
ENST00000394121
ENST00000394121.8
ENST00000450525
ENST00000450525.6
ENST00000546243
ENST00000546243.5
ENST00000584985
ENST00000584985.5
EntrezGene:7067
EntrezGene:THRA
g4507494_3p_s_at
GE81253
GO:0000003
GO:0000122
GO:0000228
GO:0000790
GO:0000976
GO:0000977
GO:0000981
GO:0001502
GO:0001503
GO:0002154
GO:0002155
GO:0002376
GO:0003013
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006629
GO:0006950
GO:0007165
GO:0007275
GO:0007420
GO:0007611
GO:0008016
GO:0008050
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0009056
GO:0009058
GO:0009409
GO:0009755
GO:0009887
GO:0017025
GO:0017055
GO:0019904
GO:0022607
GO:0030154
GO:0030218
GO:0030374
GO:0030522
GO:0030878
GO:0031490
GO:0032991
GO:0033032
GO:0033993
GO:0034641
GO:0038023
GO:0042592
GO:0043167
GO:0043226
GO:0043401
GO:0043565
GO:0044212
GO:0044877
GO:0045892
GO:0045925
GO:0045944
GO:0046872
GO:0048856
GO:0050877
GO:0050994
GO:0060509
GO:0065003
GO:0070324
GO:0090575
GO:0120162
GO:2000143
HGNC:11796
HPA009654
HQ692859
ILMN_1654613
ILMN_1661683
ILMN_1718182
IPR000536
IPR001628
IPR001723
IPR001728
IPR013088
IPR035500
J03239
J3KTF3
J3QR26
J3QRA9
J3QRW5
M24748
M24748_cds2_s_at
M24899
M24899_at
M24900
MIM:190120
MIM:614450
NM_001190918
NM_001190919
NM_003250
NM_199334
NP_001177847
NP_001177848
NP_003241
NP_955366
PF00104
PF00105
PH_hs_0030854
PR00047
PR00398
PR00546
Q6FH41
SM00399
SM00430
TC17000488.hg
TC17002195.hg
TC17002196.hg
THRA
THRA-201
THRA-202
THRA-203
THRA-204
THRA-209
UPI000002B548
UPI000002B549
UPI0000136D1E
X55004
X55005
X55005_rna1_at
X55005mRNA_3p_s_at
X55066
X55068
X55069
X55070
X55071
X55073
X55074
Y00479
Participant Of
output
Other forms of this molecule
SUMO1-K283,K389-THRA [nucleoplasm]
THRA-2 [nucleoplasm]
Inferred To
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Bos taurus)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Canis familiaris)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Danio rerio)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Drosophila melanogaster)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Gallus gallus)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Mus musculus)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Rattus norvegicus)
SUMO3-K283,K389-THRA-2 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO3 [nucleoplasm]) at 283
Coordinate
283
Modification
polySUMO3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO3 [nucleoplasm]) at 389
Coordinate
389
Modification
polySUMO3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
Orphanet
Interactors (2)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15648 MED1  1 0.591 4
 UniProt:O95971 CD160  1 0.488 2