2SUMO1:THRA-2 [nucleoplasm]

Stable Identifier
R-HSA-4719400
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
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General

PIAS2-2 SUMOylates THRA (alpha-1 isoform, THRA-2 in UniProt) with SUMO1 at lysine-283 and lysine-389. (A lysine residue corresponding to lysine-389 does not exist in the alpha-2 isoform.)

Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Liu, YY, Kogai, T, Schultz, JJ, Mody, K, Brent, GA

J. Biol. Chem. 2012
Participants
components
Participant Of
output
Inferred To
2SUMO1:THRA-2 [nucleoplasm] (Bos taurus)
2SUMO1:THRA-2 [nucleoplasm] (Caenorhabditis elegans)
2SUMO1:THRA-2 [nucleoplasm] (Canis familiaris)
2SUMO1:THRA-2 [nucleoplasm] (Danio rerio)
2SUMO1:THRA-2 [nucleoplasm] (Gallus gallus)
2SUMO1:THRA-2 [nucleoplasm] (Mus musculus)
2SUMO1:THRA-2 [nucleoplasm] (Rattus norvegicus)
2SUMO1:THRA-2 [nucleoplasm] (Xenopus tropicalis)