Reactome | SRD5A3 [endoplasmic reticulum membrane]

SRD5A3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-469663

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-oxo-5-alpha-steroid 4-dehydrogenase 3, S5A3_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        SRD5A3 reduces pPNOL to DCHOL (Homo sapiens)
        
        SRD5A3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H8P0 SRD5A3

Gene Names

SRD5A3, SRD5A2L

Chain

chain:1-318

Reference Genes

BioGPS Gene:79644 SRD5A3

COSMIC (genes):SRD5A3 SRD5A3

CTD Gene:79644 SRD5A3

dbSNP Gene:79644 SRD5A3

ENSEMBL:ENSG00000128039 SRD5A3

ENSEMBL:ENSG00000128039.13 SRD5A3

HGNC:25812 SRD5A3

KEGG Gene (Homo sapiens):79644 SRD5A3

Monarch:79644 SRD5A3

NCBI Gene:79644 SRD5A3

OMIM:611715 SRD5A3

UCSC:Q9H8P0 SRD5A3

Reference Transcript

RefSeq:NM_024592.4 SRD5A3

Other Identifiers

11720124_at

11720125_at

16966897

218800_PM_at

218800_at

222750_PM_s_at

222750_s_at

243444_PM_at

243444_at

2727763

2727764

2727773

2727775

2727776

2727779

2727780

2727781

2727782

2727783

2727784

2727786

44034_at

60159_at

69073_at

79644

8095139

A_23_P121783

A_33_P3389023

GE79734

GO:0003824

GO:0003865

GO:0005783

GO:0005789

GO:0006486

GO:0006488

GO:0006489

GO:0006629

GO:0006702

GO:0016020

GO:0016095

GO:0016491

GO:0016627

GO:0016628

GO:0019348

GO:0019408

GO:0036211

GO:0043226

GO:0047751

GO:0071704

GO:0102389

GO:1901135

HMNXSV003028932

Hs.39311.0.A1_3p_at

ILMN_1678435

PH_hs_0022108

TC04000319.hg

g12803324_3p_a_at

g13375784_3p_at

Other forms of this molecule

SRD5A3 W107* [endoplasmic reticulum membrane]

SRD5A3 Y163* [endoplasmic reticulum membrane]

SRD5A3 F69Lfs*2 [endoplasmic reticulum membrane]

SRD5A3 R142* [endoplasmic reticulum membrane]

SRD5A3 Q96* [endoplasmic reticulum membrane]

SRD5A3 S10* [endoplasmic reticulum membrane]

Inferred To

srd5a3 [endoplasmic reticulum membrane] (Danio rerio)

srd5a3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Srd5a3 [endoplasmic reticulum membrane] (Mus musculus)

Srd5a3 [endoplasmic reticulum membrane] (Rattus norvegicus)

SRD5A3 [endoplasmic reticulum membrane] (Bos taurus)

SRD5A3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

SRD5A3 [endoplasmic reticulum membrane] (Canis familiaris)

SRD5A3 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SRD5A3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

SRD5A3 [endoplasmic reticulum membrane] (Gallus gallus)

SRD5A3 [endoplasmic reticulum membrane] (Plasmodium falciparum)

SRD5A3 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

LOC100525350 [endoplasmic reticulum membrane] (Sus scrofa)

DFG10 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_078868.1

OpenTargets

ENSG00000128039

IntEnz

1.3.1.94, 1.3.1.22

GeneCards

Q9H8P0

HPA

ENSG00000128039-SRD5A3

Ensembl

ENSP00000264228, ENST00000264228, ENSG00000128039

PRO

Q9H8P0

Pharos - Targets

Q9H8P0

Orphanet

19465

HMDB Protein

HMDBP09188

© 2023 Reactome

Cite Us!