SUMOylation of NFKBIA with SUMO1

Stable Identifier
R-HSA-4656914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NFKBIA (IKBA, IkappaBalpha) is SUMOylated at lysine-21 with SUMO1 (Desterro et al. 1998, Rodriguez et al. 2001, Liu et al. 2009). SUMOylation blocks ubiquitin-mediated proteolysis of NFKBIA and thereby inhibits NF-kappaB dependent transcription and acts as an anti-inflammatory. Adenosine signaling increases SUMOylation of NFKBIA with SUMO1. Nuclear import of NFKBIA is required for SUMOylation.

Literature References
PubMed ID Title Journal Year
11124955 SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

Rodriguez, MS, Dargemont, C, Hay, RT

J. Biol. Chem. 2001
19297320 Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation

Liu, Q, Li, J, Khoury, J, Colgan, SP, Ibla, JC

J. Biol. Chem. 2009
9734360 SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

Desterro, JM, Rodriguez, MS, Hay, RT

Mol. Cell 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created