CBX4 (Pc2) SUMOylates DNMT3A with SUMO1

Stable Identifier
R-HSA-4655440
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CBX4 (Pc2) SUMOylates DNMT3A with SUMO1
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As inferred from mouse homologs, CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 at more than one lysine residue in the N-terminal (regulatory) domain. SUMOylation reduces the interaction of DNMT3A with HDAC1 and HDAC2.
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Physical Entity
PRC1 complex [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Cbx4 (Pc2) Sumoylates Dnmt3a with Sumo1 (Mus musculus)
Authored
May, B  (2013-09-28)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-03)
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