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monoSUMO1-K-TOP2B [nucleoplasm]
Stable Identifier
R-HSA-4641297
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA topoisomerase 2-beta ecNumber5.99.1.3/ecNumber, TOP2B_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
SUMOylation of TOP2B with SUMO1 (Homo sapiens)
monoSUMO1-K-TOP2B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02880 TOP2B
Gene Names
TOP2B
Chain
initiator methionine:, chain:2-1626
Reference Genes
BioGPS Gene:7155 TOP2B
COSMIC (genes):TOP2B TOP2B
CTD Gene:7155 TOP2B
dbSNP Gene:7155 TOP2B
ENSEMBL:ENSG00000077097 TOP2B
ENSEMBL_homo_sapiens_GENE:ENSG00000077097.17 TOP2B
HGNC:11990 TOP2B
KEGG Gene (Homo sapiens):7155 TOP2B
Monarch:7155 TOP2B
NCBI Gene:7155 TOP2B
OMIM:126431 TOP2B
UCSC:Q02880 TOP2B
Reference Transcript
RefSeq:NM_001068.3 TOP2B
RefSeq:NM_001330700.1 TOP2B
Other Identifiers
11716247_s_at
11749531_x_at
11757323_x_at
1581_s_at
16951601
16951644
17119370
211987_PM_at
211987_at
2666475
2666477
2666479
2666480
2666481
2666482
2666486
2666488
2666493
2666495
2666496
2666497
2666498
2666499
2666500
2666501
2666502
2666503
2666504
2666505
2666506
2666507
2666509
2666510
2666511
2666512
2666516
2666517
2666519
2666521
2666522
2666524
2666525
2666526
2666527
2666528
2666529
2666530
2666531
2666532
2666533
2666534
2666537
2666538
2666540
2666541
2666548
2666549
2666550
2666558
36571_at
7155
8085815
A_23_P121095
GE59941
GO:0000166
GO:0000712
GO:0000792
GO:0000819
GO:0001764
GO:0002376
GO:0003677
GO:0003682
GO:0003824
GO:0003916
GO:0003918
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005829
GO:0006259
GO:0006265
GO:0006281
GO:0006310
GO:0007059
GO:0007409
GO:0016853
GO:0022414
GO:0030154
GO:0030183
GO:0030900
GO:0043021
GO:0043226
GO:0045870
GO:0046872
GO:0048856
GO:0048870
GO:0070301
GO:0071318
GO:0090398
GO:0140013
GO:0140097
GO:0140657
GO:1990904
GO:2001034
HMNXSV003052746
Hs.75248.0.S1_3p_at
ILMN_1777663
M27504_s_at
PH_hs_0023447
TC03001247.hg
Z15115_at
Participates
as an output of
SUMOylation of TOP2B with SUMO1 (Homo sapiens)
Other forms of this molecule
TOP2B [nucleoplasm]
Inferred To
cin-4 [nucleoplasm]
(Caenorhabditis elegans)
top2b [nucleoplasm]
(Xenopus tropicalis)
Top2b [nucleoplasm]
(Rattus norvegicus)
Homologues of monoSUMO1-K-TOP2B [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K-TOP2B [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K-TOP2B [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K-TOP2B [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K-TOP2B [nucleoplasm]
(Gallus gallus)
monoSUMO1-K-TOP2B [nucleoplasm]
(Mus musculus)
monoSUMO1-K-TOP2B [nucleoplasm]
(Plasmodium falciparum)
monoSUMO1-K-TOP2B [nucleoplasm]
(Saccharomyces cerevisiae)
monoSUMO1-K-TOP2B [nucleoplasm]
(Schizosaccharomyces pombe)
TOP2B [nucleoplasm]
(Bos taurus)
TOP2B [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001317629.1
,
NP_001059.2
OpenTargets
ENSG00000077097
GeneCards
Q02880
ZINC - Substances
TOP2B_HUMAN
HPA
ENSG00000077097-TOP2B
ZINC target
Q02880
Ensembl
ENST00000264331
,
ENSG00000077097
,
ENSP00000264331
,
ENSP00000396704
,
ENST00000435706
PRO
Q02880
Pharos - Targets
Q02880
Orphanet
28587
HMDB Protein
HMDBP02207
PDB
4G0U
,
3QX3
,
5ZEN
,
7YQ8
,
5GWI
,
7ZBG
,
4G0W
,
5ZQF
,
4G0V
,
7QFN
,
4J3N
,
5GWJ
,
5ZRF
,
7QFO
,
5ZAD
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.558
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
2
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.527
2
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.499
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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