USP8 deubiquitinates FZD to potentiate WNT signaling

Stable Identifier
R-HSA-4641236
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP8 is a deubiquitinase that enhances WNT signaling by deubiquitinating the FZD receptor and promoting its recycling to the cell surface (Mukai et al, 2010).

Literature References
PubMed ID Title Journal Year
20495530 Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

Mukai, A, Yamamoto-Hino, M, Awano, W, Watanabe, W, Komada, M, Goto, S

EMBO J. 2010
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP8 [cytosol]

Orthologous Events
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