USP8 deubiquitinates FZD to potentiate WNT signaling

Stable Identifier
R-HSA-4641236
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP8 is a deubiquitinase that enhances WNT signaling by deubiquitinating the FZD receptor and promoting its recycling to the cell surface (Mukai et al, 2010).

Literature References
PubMed ID Title Journal Year
20495530 Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

Mukai, A, Yamamoto-Hino, M, Awano, W, Watanabe, W, Komada, M, Goto, S

EMBO J. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed