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Go!
RSPO3 [extracellular region]
Stable Identifier
R-HSA-4641195
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PWTSR, THSD2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in WNT signaling (Homo sapiens)
RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
RSPO:LGR binds ZNRF3 (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
RSPOs bind LGRs (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
RSPO:LGR:ub-ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO [extracellular region] (Homo sapiens)
RSPO3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXY4 RSPO3
Gene Names
RSPO3, PWTSR, THSD2
Chain
signal peptide:1-21, chain:22-272
Reference Genes
BioGPS Gene:84870 RSPO3
COSMIC (genes):RSPO3 RSPO3
CTD Gene:84870 RSPO3
dbSNP Gene:84870 RSPO3
ENSEMBL:ENSG00000146374 RSPO3
HGNC:20866 RSPO3
KEGG:hsa:84870 RSPO3
Monarch:84870 RSPO3
NCBI Gene:84870 RSPO3
OMIM:610574 RSPO3
UCSC:Q9BXY4 RSPO3
Reference Transcript
RefSeq:NM_032784.4 RSPO3
Other Identifiers
11724619_at
17012392
228186_PM_s_at
228186_s_at
2924860
2924861
2924862
2924863
2924864
2924865
2924866
2924870
2924871
2924877
2924878
2924879
2924880
2924882
2924883
2924884
2924888
2924889
2924890
2924891
2924892
2924894
2924896
2924897
46141_at
78860_at
8121916
84870
A_14_P102571
A_14_P108739
A_14_P127382
A_14_P135331
A_23_P111402
A_24_P106542
GE587039
GE83517
GO:0001525
GO:0001974
GO:0002040
GO:0005102
GO:0005109
GO:0005576
GO:0008201
GO:0016055
GO:0030177
GO:0060070
GO:0060670
GO:0090263
GO:2000052
GO:2000096
HMNXSV003013907
HMNXSV003051913
Hs.58328.0.A1_3p_s_at
ILMN_1681983
PH_hs_0008165
PH_hs_0008181
TC06000968.hg
Participates
as an output of
RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)
as a member of
RSPO [extracellular region] (Homo sapiens)
Inferred To
RSPO3 [extracellular region]
(Bos taurus)
RSPO3 [extracellular region]
(Canis familiaris)
RSPO3 [extracellular region]
(Gallus gallus)
RSPO3 [extracellular region]
(Sus scrofa)
rspo3 [extracellular region]
(Danio rerio)
rspo3 [extracellular region]
(Xenopus tropicalis)
Rspo3 [extracellular region]
(Mus musculus)
Rspo3 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_116173.2
ENSEMBL
ENST00000368317
,
ENST00000356698
,
ENSP00000349131
,
ENSP00000357300
OpenTargets
ENSG00000146374
HPA
ENSG00000146374-RSPO3
PRO
Q9BXY4
Pharos - Targets
Q9BXY4
GlyGen
Q9BXY4
HMDB Protein
HMDBP14503
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