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Go!
LGR5 [plasma membrane]
Stable Identifier
R-HSA-4641171
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPR49, GPR67
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
RSPO:LGR binds ZNRF3 (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
RSPOs bind LGRs (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)
RSPO:LGR:ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
RSPO:LGR [plasma membrane] (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
RSPO:LGR:ub-ZNRF3,RNF43 [plasma membrane] (Homo sapiens)
LGR [plasma membrane] (Homo sapiens)
LGR5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75473 LGR5
Gene Names
LGR5, GPR49, GPR67
Chain
signal peptide:1-21, chain:22-907
Reference Genes
BioGPS Gene:8549 LGR5
COSMIC (genes):LGR5 LGR5
CTD Gene:8549 LGR5
dbSNP Gene:8549 LGR5
ENSEMBL:ENSG00000139292 LGR5
HGNC:4504 LGR5
KEGG:hsa:8549 LGR5
Monarch:8549 LGR5
NCBI Gene:8549 LGR5
OMIM:606667 LGR5
UCSC:O75473 LGR5
Reference Transcript
RefSeq:NM_001277226.1 LGR5
RefSeq:NM_003667.3 LGR5
RefSeq:NM_001277227.1 LGR5
Other Identifiers
11733962_a_at
11759120_a_at
16754134
210393_PM_at
210393_at
213880_PM_at
213880_at
3422145
3422146
3422162
3422166
3422167
3422175
3422176
3422177
3422179
3422180
3422181
3422182
3422183
3422184
3422185
3422186
3422188
3422189
3422191
3422192
3422193
3422194
3422195
3422196
3422197
3422198
3422199
3422200
3422201
3422202
41073_at
41074_at
7957140
8549
A_23_P98974
GE61853
GE629022
GO:0001942
GO:0004888
GO:0004930
GO:0005515
GO:0005654
GO:0005794
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0008528
GO:0009755
GO:0009994
GO:0016020
GO:0016500
GO:0022414
GO:0030154
GO:0032588
GO:0042127
GO:0043226
GO:0048839
GO:0048856
GO:0060089
GO:0090263
GO:2001013
HMNXSV003007764
HMNXSV003042542
Hs.285529.1.A1_3p_at
ILMN_1702310
PH_hs_0010030
TC12000624.hg
g3366801_3p_at
Participates
as a member of
LGR [plasma membrane] (Homo sapiens)
Inferred To
Lgr5 [plasma membrane]
(Mus musculus)
Lgr5 [plasma membrane]
(Rattus norvegicus)
lgr5 [plasma membrane]
(Xenopus tropicalis)
LGR5 [plasma membrane]
(Bos taurus)
LGR5 [plasma membrane]
(Gallus gallus)
LGR5 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001264156.1
,
NP_001264155.1
,
NP_003658.1
Guide to Pharmacology - Targets
148
ENSEMBL
ENST00000266674
,
ENST00000540815
,
ENSP00000441035
,
ENST00000536515
,
ENSP00000266674
,
ENSP00000443033
OpenTargets
ENSG00000139292
HPA
ENSG00000139292-LGR5
PRO
O75473
Pharos - Targets
O75473
GlyGen
O75473
PDB
4BSR
,
4UFS
,
4BSS
,
4UFR
,
4BSU
,
4BST
,
4KNG
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