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HECW1 [cytosol]
Stable Identifier
R-HSA-4641156
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDL1, KIAA0322
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of DVL (Homo sapiens)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)
DVL1:HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
DVL1 is ubiquitinated by HECW1 (Homo sapiens)
DVL1:HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
ub-DVL1:HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
ub-DVL1:HECW1 [cytosol] (Homo sapiens)
HECW1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q76N89 HECW1
Gene Names
HECW1, KIAA0322, NEDL1
Chain
chain:1-1606
Reference Genes
BioGPS Gene:23072 HECW1
COSMIC (genes):HECW1 HECW1
CTD Gene:23072 HECW1
dbSNP Gene:23072 HECW1
ENSEMBL:ENSG00000002746 HECW1
HGNC:22195 HECW1
KEGG:hsa:23072 HECW1
Monarch:23072 HECW1
NCBI Gene:23072 HECW1
OMIM:610384 HECW1
UCSC:Q76N89 HECW1
Reference Transcript
RefSeq:NM_001287059.1 HECW1
RefSeq:XM_017011886.1 HECW1
RefSeq:NM_015052.4 HECW1
RefSeq:XM_017011889.1 HECW1
Other Identifiers
11735250_a_at
11735251_at
17045486
210331_PM_at
210331_at
215584_PM_at
215584_at
23072
243163_PM_at
243163_at
2999335
2999337
2999338
2999339
2999345
2999346
2999347
2999351
2999362
2999369
2999374
2999375
2999378
2999380
2999381
2999382
2999383
2999385
2999386
2999387
2999388
2999389
2999392
2999393
2999395
2999396
2999397
2999398
2999401
2999402
2999404
2999406
2999408
2999409
2999410
2999411
2999414
2999415
2999416
2999423
2999424
2999425
2999427
2999428
2999432
2999433
2999467
2999468
2999469
2999470
2999471
2999472
2999473
2999482
2999484
2999486
2999487
35011_at
55068_at
8132465
A_23_P319027
A_32_P166422
GE476124
GE53056
GE535174
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0006511
GO:0016567
GO:0016740
GO:0048814
GO:0061630
GO:0090090
GO:0140096
HMNXSV003025225
HMNXSV003033352
HMNXSV003042895
Hs.153661.0.A1_3p_at
Hs.287538.0.S1_3p_at
ILMN_1790645
PH_hs_0041193
TC07000261.hg
g10039442_3p_at
Participates
as an output of
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
as an input of
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)
as a component of
ub-DVL1:HECW1 [cytosol] (Homo sapiens)
DVL1:HECW1 [cytosol] (Homo sapiens)
Inferred To
HECW1 [cytosol]
(Bos taurus)
HECW1 [cytosol]
(Canis familiaris)
HECW1 [cytosol]
(Sus scrofa)
Hecw1 [cytosol]
(Mus musculus)
Hecw1 [cytosol]
(Rattus norvegicus)
hecw-1 [cytosol]
(Caenorhabditis elegans)
Hecw [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000379228
,
ENST00000395891
,
ENST00000453890
,
ENSP00000407774
,
ENSG00000002746
OpenTargets
ENSG00000002746
GeneCards
HECW1
HPA
ENSG00000002746-HECW1
PRO
Q76N89
Pharos - Targets
Q76N89
GlyGen
Q76N89
PDB
3L4H
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5SQQ9-2 VAX1
0.556
3
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