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monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
Stable Identifier
R-HSA-4616030
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 1, HDAC1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
SUMOylation of HDAC1 with SUMO1 (Homo sapiens)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13547 HDAC1
Gene Names
HDAC1, RPD3L1
Chain
chain:1-482
Reference Genes
BioGPS Gene:3065 HDAC1
COSMIC (genes):HDAC1 HDAC1
CTD Gene:3065 HDAC1
dbSNP Gene:3065 HDAC1
ENSEMBL:ENSG00000116478 HDAC1
ENSEMBL_homo_sapiens_GENE:ENSG00000116478.12 HDAC1
HGNC:4852 HDAC1
KEGG Gene (Homo sapiens):3065 HDAC1
Monarch:3065 HDAC1
NCBI Gene:3065 HDAC1
OMIM:601241 HDAC1
Reference Transcript
RefSeq:NM_004964.2 HDAC1
Other Identifiers
11747406_a_at
11755718_s_at
16662077
201209_PM_at
201209_at
2328869
2328870
2328872
2328873
2328878
2328879
2328882
2328885
2328889
2328890
2328891
2328892
2328894
2328896
2328898
2328900
2381219
2927725
3065
38771_at
476_s_at
7899774
A_14_P114672
A_23_P114656
D50405_at
GE57241
GO:0000118
GO:0000122
GO:0000228
GO:0000785
GO:0000792
GO:0000976
GO:0000978
GO:0000979
GO:0001046
GO:0001222
GO:0002039
GO:0003677
GO:0003682
GO:0003714
GO:0003824
GO:0004407
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006346
GO:0006351
GO:0006355
GO:0006357
GO:0006476
GO:0007492
GO:0007623
GO:0008284
GO:0009913
GO:0010628
GO:0010629
GO:0012501
GO:0016575
GO:0016581
GO:0016787
GO:0017053
GO:0019899
GO:0021766
GO:0023052
GO:0030154
GO:0030182
GO:0030336
GO:0030512
GO:0031492
GO:0032922
GO:0032991
GO:0033558
GO:0035851
GO:0036120
GO:0036211
GO:0042475
GO:0042659
GO:0042733
GO:0042826
GO:0043025
GO:0043066
GO:0043124
GO:0043226
GO:0043922
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0048511
GO:0048661
GO:0048709
GO:0048714
GO:0048856
GO:0048870
GO:0051059
GO:0052548
GO:0060766
GO:0060789
GO:0061029
GO:0061198
GO:0061629
GO:0070822
GO:0070888
GO:0090090
GO:0140096
GO:0140110
GO:0140297
GO:0160008
GO:0160009
GO:1900221
GO:1902455
GO:1902459
GO:1990841
GO:2000273
GO:2000736
GO:2001243
HMNXSV003006637
ILMN_1727458
PH_hs_0004954
TC01000427.hg
U50079_s_at
g13128859_3p_at
Participates
as an output of
SUMOylation of HDAC1 with SUMO1 (Homo sapiens)
Other forms of this molecule
HDAC1 [nucleoplasm]
Inferred To
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(Plasmodium falciparum)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(Sus scrofa)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(Xenopus tropicalis)
Hdac1 [nucleoplasm]
(Mus musculus)
Hdac1 [nucleoplasm]
(Rattus norvegicus)
clr6 [nucleoplasm]
(Schizosaccharomyces pombe)
HDAC1 [nucleoplasm]
(Bos taurus)
HDAC1 [nucleoplasm]
(Gallus gallus)
RPD3 [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 444
Coordinate
444
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 476
Coordinate
476
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_004955.2
ZINC - World Drugs
HDAC1_HUMAN
Guide to Pharmacology - Targets
2658
OpenTargets
ENSG00000116478
ZINC - FDA approved
HDAC1_HUMAN
ZINC - Substances
HDAC1_HUMAN
ZINC target
Q13547
ZINC - Biogenic
HDAC1_HUMAN
PRO
Q13547
PDB
6Z2J
,
7SME
,
7AO9
,
7AO8
,
7AOA
,
6Z2K
,
5ICN
,
4BKX
ZINC - Investigational
HDAC1_HUMAN
GeneCards
Q13547
HPA
ENSG00000116478-HDAC1
Ensembl
ENST00000373548
,
ENSG00000116478
,
ENSP00000362649
Pharos - Targets
Q13547
ZINC - Predictions - Purchasable
HDAC1_HUMAN
Interactors (173)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.955
18
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.951
19
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.946
21
UniProt:Q9UKL0 RCOR1
1
RCOR1 [nucleoplasm]
(R-HSA-996766)
0.945
15
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.929
16
UniProt:Q8N108 MIER1
0.926
12
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.924
15
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.918
13
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.916
14
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.909
12
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.899
10
UniProt:Q9UBB5 MBD2
1
MBD2 [nucleoplasm]
(R-HSA-427367)
0.894
10
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.877
10
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.855
12
UniProt:Q92618 ZN516
0.84
12
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.837
8
UniProt:Q5PSV4 BRM1L
0.837
8
UniProt:Q6PJG2 MDEAS
0.837
9
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.837
9
UniProt:Q9H7L9 SUDS3
2
K63polyUb-SUDS3 [nucleoplasm]
(R-HSA-6782790)
SUDS3 [nucleoplasm]
(R-HSA-351696)
0.837
8
UniProt:Q9NP66 HM20A
0.837
9
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.837
9
UniProt:Q9H147 TDIF1
0.837
10
UniProt:Q14865 ARID5B
1
ARID5B [nucleoplasm]
(R-HSA-5423050)
0.835
9
UniProt:Q9NP50 SHCAF
0.835
10
UniProt:Q9HCU9 BRMS1
1
BRMS1 [nucleoplasm]
(R-HSA-4650034)
0.832
8
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.805
9
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.794
9
UniProt:O75182 SIN3B
1
SIN3B [nucleoplasm]
(R-HSA-3006450)
0.788
7
UniProt:Q14687 GSE1
0.788
7
UniProt:Q9P0W2 HMG20B
1
HMG20B [nucleoplasm]
(R-HSA-996745)
0.788
7
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.788
8
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.788
7
UniProt:Q7Z589 EMSY
0.788
7
UniProt:Q9UBW7 ZMYM2
6
ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839016)
ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604544)
ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol]
(R-HSA-9703309)
ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol]
(R-HSA-9703319)
ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol]
(R-HSA-9703310)
ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol]
(R-HSA-9703311)
0.788
6
UniProt:O14519 CDKA1
0.788
8
UniProt:O75362 ZNF217
1
ZNF217 [nucleoplasm]
(R-HSA-9011738)
0.788
7
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.788
7
UniProt:Q96N64 PWP2A
0.787
8
UniProt:Q6PH81 CP087
0.773
8
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.759
4
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.725
6
UniProt:Q92766 RREB1
0.725
6
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.725
4
UniProt:Q9HAJ7 SAP30L
1
SAP30L [nucleoplasm]
(R-HSA-351698)
0.725
6
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.725
5
UniProt:O15417 TNC18
0.725
5
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.725
4
UniProt:Q96QT6 PHF12
0.725
7
UniProt:Q9P2R6 RERE
0.725
6
UniProt:Q9H0E3 SAP130
1
SAP130 [nucleoplasm]
(R-HSA-3006732)
0.725
6
UniProt:Q14202 ZMYM3
0.725
6
UniProt:Q9P2K3 RCOR3
0.725
6
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.725
8
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.725
7
UniProt:Q8WUU5 GATD1
0.725
5
UniProt:Q96PN7 TREF1
0.725
6
UniProt:Q8N680 ZBTB2
0.725
5
UniProt:Q9H160 ING2
2
monoSUMO1-K195-ING2 [nucleoplasm]
(R-HSA-4086075)
ING2 [nucleoplasm]
(R-HSA-3215167)
0.725
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.713
7
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.702
6
UniProt:Q9C0K0 BC11B
0.695
5
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.69
4
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.688
3
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.656
6
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.646
5
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.643
3
UniProt:Q8IZ40 RCOR2
0.643
5
UniProt:O15014 ZN609
0.643
3
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.643
4
UniProt:Q96BD5 PHF21A
1
PHF21A [nucleoplasm]
(R-HSA-996754)
0.643
5
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.643
10
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.643
4
UniProt:O95785 WIZ
0.643
3
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.643
5
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.643
4
UniProt:Q8N344 MIER2
0.643
5
UniProt:Q9H165 BCL11A
2
BCL11A(1-219)insDHPPA-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713444)
BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713447)
0.643
4
UniProt:P0C0S8 H2AC11
11
K63polyUb-HIST1H2AG [nucleoplasm]
(R-HSA-6783237)
Ub-HIST1H2AG [nucleoplasm]
(R-HSA-6782508)
Ack6-HIST1H2AG [nucleoplasm]
(R-HSA-4568595)
Me2aR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244582)
MeR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244560)
Me2aR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244587)
MeR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244623)
Me2aR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229305)
MeR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229206)
HIST1H2AG [nucleoplasm]
(R-HSA-212084)
Ack-HIST1H2AG [nucleoplasm]
(R-HSA-4551311)
0.643
3
UniProt:Q4LE39 ARID4B
1
ARID4B [nucleoplasm]
(R-HSA-2976647)
0.643
5
UniProt:Q9ULU4 ZMYD8
0.643
3
UniProt:Q9P281 BAHC1
0.643
3
UniProt:P61758 VBP1
1
VBP1 [cytosol]
(R-HSA-379543)
0.643
3
UniProt:Q96KM6 ZNF512B
1
ZNF512B [cytosol]
(R-HSA-9715175)
0.643
3
UniProt:P29374 ARID4A
1
ARID4A [nucleoplasm]
(R-HSA-4650032)
0.643
5
UniProt:Q7Z3K6 MIER3
0.643
5
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.643
3
UniProt:Q8N1G0 ZN687
0.643
3
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
5
UniProt:Q96K83 ZNF521
1
ZNF521 [nucleoplasm]
(R-HSA-3222324)
0.643
3
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.643
3
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
4
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.642
3
UniProt:Q2TB10 ZN800
0.615
3
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.597
4
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.597
7
UniProt:Q9Y618 NCOR2
2
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
NCOR2 [nucleoplasm]
(R-HSA-442469)
0.589
2
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.589
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.576
4
UniProt:Q9NQX1 PRDM5
0.576
3
UniProt:O60341-1 KDM1A
0.564
2
UniProt:O95365 ZBT7A
0.564
2
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.564
2
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.558
5
UniProt:Q9UJW3 DNMT3L
1
DNMT3L [nucleoplasm]
(R-HSA-5334123)
0.544
3
UniProt:Q99497 PARK7
7
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PARK7 [nucleoplasm]
(R-HSA-3900141)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.537
4
UniProt:P22670 RFX1
0.534
2
UniProt:Q8N5A5 ZGPAT
0.532
3
UniProt:Q17R98 ZN827
0.527
2
UniProt:Q9P2K3-3 RCOR3
0.527
2
UniProt:Q8IV32 CCD71
0.527
3
UniProt:Q969G3 SMARCE1
1
SMARCE1 [nucleoplasm]
(R-HSA-389258)
0.527
2
UniProt:Q6NUJ5 PWP2B
0.527
2
UniProt:Q92526 CCT6B
1
CCT6B [cytosol]
(R-HSA-5216201)
0.527
3
UniProt:Q14839-2 CHD4
0.527
2
UniProt:P56545 CTBP2
1
CTBP2 [nucleoplasm]
(R-HSA-5333990)
0.527
2
UniProt:Q4LE39-2 ARID4B
0.527
2
UniProt:Q9UKL3 CASP8AP2
2
monoSUMO1-K1813-CASP8AP2 [nucleoplasm]
(R-HSA-3927850)
CASP8AP2 [nucleoplasm]
(R-HSA-3927945)
0.527
3
UniProt:Q9UHF7 TRPS1
0.527
2
UniProt:Q9R190 Mta2
1
Mta2 [nucleoplasm]
(R-MMU-5096453)
0.527
2
UniProt:Q9UHV9 PFDN2
1
PFDN2 [cytosol]
(R-HSA-379544)
0.527
2
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
3
UniProt:O60925 PFDN1
1
PFDN1 [cytosol]
(R-HSA-379541)
0.527
2
UniProt:Q9UK53 ING1
0.527
4
UniProt:P29375-2 KDM5A
0.527
2
UniProt:Q9Y232-2 CDYL
0.527
2
UniProt:Q96BD5-2 PHF21A
0.527
2
UniProt:Q9H2P0 ADNP
0.527
2
UniProt:Q8WY36 BBX
0.527
2
UniProt:Q9ULD9 ZN608
0.527
2
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.527
3
UniProt:IL2 ENSG00000109471
0.527
3
UniProt:O75182-2 SIN3B
0.527
2
UniProt:Q09028-2 RBBP4
0.527
2
UniProt:Q5T5X7 BEND3
0.527
2
UniProt:Q92610 ZN592
0.527
2
UniProt:Q8WWY6 MB3L1
0.527
3
UniProt:Q96EK2 PF21B
0.527
3
UniProt:Q9P2Y4 ZN219
0.527
5
UniProt:O15212 PFDN6
1
PFDN6 [cytosol]
(R-HSA-379547)
0.527
2
UniProt:Q8TDI0 CHD5
0.527
4
UniProt:Q8TBE0 BAHD1
0.527
3
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
4
UniProt:Q96KQ7-2 EHMT2
0.527
2
UniProt:Q9UHJ3 SMBT1
0.527
2
UniProt:P29375 KDM5A
1
KDM5A [nucleoplasm]
(R-HSA-3215029)
0.527
3
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.527
2
UniProt:Q9Y232 CDYL
0.527
4
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.527
4
UniProt:Q9NSC2 SALL1
1
SALL1 [nucleoplasm]
(R-HSA-452500)
0.527
2
UniProt:Q8N4J0 CARNMT1
1
CARNMT1 [cytosol]
(R-HSA-8876689)
0.527
3
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.524
2
UniProt:P43355 MAGA1
0.524
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.524
3
UniProt:Q9UIS9 MBD1
2
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
MBD1 [nucleoplasm]
(R-HSA-417134)
0.524
2
UniProt:Q92841-4 DDX17
0.524
3
UniProt:O00422 SAP18
1
SAP18 [nucleoplasm]
(R-HSA-351694)
0.524
2
UniProt:P03129 VE7
0.524
2
UniProt:Q66K89 E4F1
0.524
3
UniProt:P29128 ICP0
0.524
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.524
2
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.512
4
UniProt:Q92949 FOXJ1
0.508
2
UniProt:Q13227 GPS2
1
GPS2 [nucleoplasm]
(R-HSA-351642)
0.499
2
IntAct:EBI-2694074 MDM2
0.499
2
UniProt:Q15466 NR0B2
1
NR0B2 [nucleoplasm]
(R-HSA-376312)
0.499
2
UniProt:P51610 HCFC1
2
HCFC1 [nucleoplasm]
(R-HSA-1592209)
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
0.499
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.499
2
UniProt:Q99684 GFI1
1
GFI1 [nucleoplasm]
(R-HSA-2980932)
0.499
4
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.483
2
UniProt:A4PIW0 A4PIW0
0.462
3
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
2
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.462
4
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