Reactome | SYMPK [nucleoplasm]

SYMPK [nucleoplasm]

Stable Identifier

R-HSA-4615988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Symplekin, SYMPK_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92797 SYMPK

Gene Names

SYMPK, SPK

Chain

chain:1-1274

Reference Genes

BioGPS Gene:8189 SYMPK

COSMIC (genes):SYMPK SYMPK

CTD Gene:8189 SYMPK

dbSNP Gene:8189 SYMPK

ENSEMBL:ENSG00000125755 SYMPK

ENSEMBL_homo_sapiens_GENE:ENSG00000125755.19 SYMPK

HGNC:22935 SYMPK

KEGG Gene (Homo sapiens):8189 SYMPK

Monarch:8189 SYMPK

NCBI Gene:8189 SYMPK

OMIM:602388 SYMPK

UCSC:Q92797 SYMPK

Reference Transcript

Other Identifiers

11733741_x_at

11749529_a_at

16873453

202339_3p_at

202339_PM_at

202339_at

32402_PM_s_at

32402_s_at

3865716

3865717

3865718

3865719

3865720

3865721

3865722

3865724

3865727

3865728

3865729

3865731

3865737

3865738

3865739

3865740

3865742

3865744

3865745

3865747

3865748

3865749

3865750

3865751

3865753

3865754

3865756

3865757

3865759

3865760

3865769

52396_s_at

8037695

8189

A_23_P78808

A_33_P3327702

GE62728

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005847

GO:0005856

GO:0005886

GO:0005923

GO:0006378

GO:0006397

GO:0007155

GO:0016020

GO:0016071

GO:0016604

GO:0032091

GO:0043226

GO:0070161

GO:0097165

HMNXSV003048910

ILMN_1802089

PH_hs_0024297

TC19001635.hg

U88726_at

g4759195_3p_at

g4759195_3p_s_at

Participates

as a component of

CPSF [nucleoplasm] (Homo sapiens)

Inferred To

pta1 [nucleoplasm] (Schizosaccharomyces pombe)

Sympk [nucleoplasm] (Mus musculus)

Sympk [nucleoplasm] (Rattus norvegicus)

SYMPK [nucleoplasm] (Bos taurus)

SYMPK [nucleoplasm] (Canis familiaris)

SYMPK [nucleoplasm] (Sus scrofa)

PTA1 [nucleoplasm] (Saccharomyces cerevisiae)

sympk [nucleoplasm] (Dictyostelium discoideum)

symk-1 [nucleoplasm] (Caenorhabditis elegans)

Sym [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SYMPK [nucleoplasm] (Danio rerio)

Ghost homologue of SYMPK [nucleoplasm] (Gallus gallus)

Ghost homologue of SYMPK [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_005259343.1, XP_011525656.1, NP_004810.2

OpenTargets

ENSG00000125755

GeneCards

Q92797

HPA

ENSG00000125755-SYMPK

Ensembl

ENSG00000125755, ENST00000245934, ENSP00000245934

PRO

Q92797

Pharos - Targets

Q92797

PDB

3ODR, 3O2T, 3O2Q, 4H3K, 3O2S, 4H3H, 3ODS, 6V4X

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3

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