Reactome | SYMPK [nucleoplasm]

SYMPK [nucleoplasm]

Stable Identifier

R-HSA-4615988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Symplekin, SYMPK_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92797 SYMPK

Gene Names

SYMPK, SPK

Chain

chain:1-1274

Reference Genes

BioGPS Gene:8189 Q927972

COSMIC (genes):SYMPK SYMPK

CTD Gene:8189 Q927972

dbSNP Gene:8189 SYMPK

ENSEMBL:ENSG00000125755 SYMPK

HGNC:22935 Q927972

KEGG:hsa:8189 Q927972

Monarch:8189 Q927972

NCBI Gene:8189 Q927972

OMIM:602388 Q927972

UCSC:Q92797 Q927972

Reference Transcript

Participates

as an input of

Formation of the core cleavage and polyadenylation complex (Homo sapiens)

as a component of

Inferred To

pta1 [nucleoplasm] (Schizosaccharomyces pombe)

Sympk [nucleoplasm] (Mus musculus)

Sympk [nucleoplasm] (Rattus norvegicus)

SYMPK [nucleoplasm] (Bos taurus)

SYMPK [nucleoplasm] (Canis familiaris)

SYMPK [nucleoplasm] (Sus scrofa)

PTA1 [nucleoplasm] (Saccharomyces cerevisiae)

sympk [nucleoplasm] (Danio rerio)

sympk [nucleoplasm] (Dictyostelium discoideum)

sympk [nucleoplasm] (Xenopus tropicalis)

symk-1 [nucleoplasm] (Caenorhabditis elegans)

Sym [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SYMPK [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

XP_005259343.1, XP_011525656.1, NP_004810.2, XP_054178243.1

OpenTargets

ENSG00000125755

ENSEMBL

ENST00000245934, ENSP00000520453, ENSG00000125755, ENSP00000245934, ENST00000715464

HPA

ENSG00000125755-SYMPK

GeneCards

SYMPK

PRO

Q92797

Pharos - Targets

Q92797

GlyGen

Q92797

PDB

4H3H, 3O2T, 3O2S, 6V4X, 4H3K, 3ODS, 3O2Q, 3ODR

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2I0 CPSF2	1	CPSF2 [nucleoplasm] (R-HSA-71991)	0.847	7
UniProt:Q9UKF6 CPSF3	2	Ub-K63-CPSF3 [nucleoplasm] (R-HSA-9970273) CPSF3 [nucleoplasm] (R-HSA-71993)	0.725	5
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.669	3
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.564	2
UniProt:Q9NP77-1 SSU72			0.558	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.527	3
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	4
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.527	3
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.527	2
UniProt:Q9BZB8 CPEB1			0.527	3
UniProt:Q9NX40 OCAD1			0.527	3
UniProt:P33240 CSTF2	1	CSTF2 [nucleoplasm] (R-HSA-72003)	0.499	2
UniProt:Q9H6E5 TUT1	1	TUT1 [nucleoplasm] (R-HSA-9970846)	0.462	2

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