RANBP2 SUMOylates HDAC4 with SUMO2,3

Stable Identifier
R-HSA-4615987
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RANBP2 SUMOylates HDAC4 with SUMO2,3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RANBP2 SUMOylates HDAC4 at lysine-559 with SUMO2,3 (Kirsh et al. 2002). SUMOylation increases transcription repression by HDAC4.
Literature References
PubMed ID Title Journal Year
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Kirsh, O, Seeler, JS, Pichler, A, Gast, A, Müller, S, Miska, E, Mathieu, M, Harel-Bellan, A, Kouzarides, T, Melchior, F, Dejean, A

EMBO J. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Danio rerio)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Sus scrofa)
Authored
May, B  (2013-09-21)
Reviewed
Lu, J  (2017-01-22)
Matunis, MJ  (2017-01-22)
Yang, WC  (2017-01-22)
Created
May, B  (2013-09-27)
Cite Us!