Reactome | SUMOylation of HDAC1 with SUMO1

SUMOylation of HDAC1 with SUMO1

Stable Identifier

R-HSA-4615889

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HDAC1 is SUMOylated at lysine-444 and lysine-476 with SUMO1 (Kirsh et al. 2002, David et al. 2002, Cheng et al. 2004, Citro et al. 2013). SUMOylation with SUMO1 enhances transcription repression by HDAC1 and promotes degradation of HDAC1 (Citro et al. 2013). HDAC1 can also be SUMOylated with SUMO2, which enhances stability of HDAC1 (Citro et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
24068740	A role for paralog-specific sumoylation in histone deacetylase 1 stability Hay, RT, Chiocca, S, Seiser, C, Jaffray, E, Citro, S	J Mol Cell Biol	2013
15199155	SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 Yeh, ET, Cheng, J, Wang, D, Wang, Z	Mol. Cell. Biol.	2004
11960997	SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities David, G, DePinho, RA, Neptune, MA	J. Biol. Chem.	2002
12032081	The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E	EMBO J.	2002