SUMOylation of HDAC1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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HDAC1 is SUMOylated at lysine-444 and lysine-476 with SUMO1 (Kirsh et al. 2002, David et al. 2002, Cheng et al. 2004, Citro et al. 2013). SUMOylation with SUMO1 enhances transcription repression by HDAC1 and promotes degradation of HDAC1 (Citro et al. 2013). HDAC1 can also be SUMOylated with SUMO2, which enhances stability of HDAC1 (Citro et al. 2013).
Literature References
PubMed ID Title Journal Year
24068740 A role for paralog-specific sumoylation in histone deacetylase 1 stability

Hay, RT, Chiocca, S, Seiser, C, Jaffray, E, Citro, S

J Mol Cell Biol 2013
15199155 SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1

Yeh, ET, Cheng, J, Wang, D, Wang, Z

Mol. Cell. Biol. 2004
11960997 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities

David, G, DePinho, RA, Neptune, MA

J. Biol. Chem. 2002
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E

EMBO J. 2002
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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