PIAS2-2 SUMOylates SUZ12 with SUMO1

Stable Identifier
R-HSA-4615873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS2-2 SUMOylates SUZ12 with SUMO1
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PIAS2-2 (PIASxbeta) SUMOylates SUZ12, a subunit of the Polycomb Repressive Complex 2 (PRC2), at lysine-75 with SUMO1 (Riising et al. 2008). SUMOyation does not affect the repression of transcription by PRC2. The effect of SUMOylation on PRC2 function is unknown. The EZH2 subunit of PRC2 can also be SUMOylated at multiple positions.

Literature References
PubMed ID Title Journal Year
18628979 The polycomb repressive complex 2 is a potential target of SUMO modifications

Helin, K, Chiocca, S, Boggio, R, Riising, EM, Pasini, D

PLoS ONE 2008
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Catalyst Activity

SUMO transferase activity of PIAS2-2 [nucleoplasm]

Physical Entity
PIAS2-2 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Danio rerio)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-09-21)
Reviewed
Matunis, MJ  (2017-01-22)
Yang, WC  (2017-01-22)
Lu, J  (2017-01-22)
Created
May, B  (2013-09-27)
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