RANBP2 SUMOylates HDAC4 with SUMO1

Stable Identifier
R-HSA-4615872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RANBP2 SUMOylates HDAC4 at lysine-559 with SUMO1 (Kirsh et al. 2002, Knipscheer et al. 2008). SUMOylation increases transcription repression by HDAC4.

Literature References
PubMed ID Title Journal Year
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P

Mol. Cell 2008
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E

EMBO J. 2002
Participants
Participates
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Orthologous Events
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