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SCRIB [cytosol]
Stable Identifier
R-HSA-4608858
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CRIB, KIAA0147, LAP4, SCRB1, VARTUL
Locations in the PathwayBrowser for interactor UniProt:P53778 MAPK12
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)
SCRIB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14160 SCRIB
Gene Names
SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Chain
chain:1-1655
Reference Genes
BioGPS Gene:23513 SCRIB
COSMIC (genes):SCRIB SCRIB
CTD Gene:23513 SCRIB
dbSNP Gene:23513 SCRIB
ENSEMBL:ENSG00000180900 SCRIB
HGNC:30377 SCRIB
KEGG:hsa:23513 SCRIB
Monarch:23513 SCRIB
NCBI Gene:23513 SCRIB
OMIM:607733 SCRIB
UCSC:Q14160 SCRIB
Reference Transcript
RefSeq:NM_182706.4 SCRIB
RefSeq:NM_015356.4 SCRIB
Other Identifiers
11721210_a_at
11721211_x_at
11744785_x_at
17082263
212556_PM_at
212556_at
23513
3157752
3157753
3157754
3157755
3157756
3157757
3157758
3157759
3157760
3157761
3157762
3157763
3157764
3157765
3157766
3157767
3157768
3157769
3157770
3157771
3157772
3157774
3157776
3157777
3157778
3157781
3157782
3157783
3157784
3157785
3157786
3157787
3157788
3157790
3157791
3157792
3157794
3157795
3157796
3157797
3157798
3157800
3157801
3157802
3157803
3157804
3157805
3157806
3157807
3157808
3157809
3157810
3157811
3157812
3157813
3157814
3157816
34743_at
8153497
81576_at
A_23_P159039
D63481_at
GO:0001768
GO:0001772
GO:0001843
GO:0001921
GO:0002093
GO:0005515
GO:0005654
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0006886
GO:0007155
GO:0007163
GO:0008104
GO:0008283
GO:0010669
GO:0012501
GO:0014069
GO:0016020
GO:0016080
GO:0016192
GO:0016323
GO:0016331
GO:0016477
GO:0019901
GO:0021747
GO:0030027
GO:0030054
GO:0030154
GO:0030859
GO:0031252
GO:0032729
GO:0034750
GO:0035089
GO:0035591
GO:0035748
GO:0036342
GO:0042060
GO:0042734
GO:0042995
GO:0043065
GO:0043113
GO:0043226
GO:0043615
GO:0044291
GO:0045197
GO:0045202
GO:0045211
GO:0045296
GO:0045930
GO:0046007
GO:0048488
GO:0048856
GO:0048870
GO:0050918
GO:0060088
GO:0060090
GO:0060122
GO:0060561
GO:0060603
GO:0070062
GO:0070161
GO:0071896
GO:0072659
GO:0090630
GO:0098609
GO:0098793
GO:0098794
GO:0098887
GO:0098968
GO:0098978
GO:0099003
GO:0099147
GO:0099149
HMNXSV003014612
Hs.239784.0.S1_3p_at
Hs.239784.0.S1_3p_x_at
ILMN_1695181
ILMN_1726516
ILMN_2324029
PH_hs_0020510
TC08001732.hg
Participates
as a candidate of
RND2 effectors [cytosol] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
as an input of
SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)
as a component of
VANGL2:SCRIB [plasma membrane] (Homo sapiens)
Inferred To
scrib [cytosol]
(Danio rerio)
scrib [cytosol]
(Drosophila melanogaster)
Scrib [cytosol]
(Mus musculus)
Scrib [cytosol]
(Rattus norvegicus)
SCRIB [cytosol]
(Bos taurus)
SCRIB [cytosol]
(Canis familiaris)
SCRIB [cytosol]
(Sus scrofa)
let-413 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_874365.3
,
NP_056171.3
OpenTargets
ENSG00000180900
ENSEMBL
ENST00000320476
,
ENST00000356994
,
ENST00000612204
,
ENST00000611528
,
ENSP00000366756
,
ENSP00000479898
,
ENSP00000482406
,
ENST00000377533
,
ENST00000622455
,
ENSP00000484041
,
ENSP00000349486
,
ENSP00000322938
HPA
ENSG00000180900-SCRIB
PRO
Q14160
Pharos - Targets
Q14160
GlyGen
Q14160
PDB
6MYE
,
8B8O
,
8BIA
,
6XA8
,
6XA7
,
6MYF
,
7QS9
,
7JO7
,
7QSA
,
8CD3
,
6ESP
,
8BJ0
,
8B87
,
7QTP
,
8B82
,
6EEY
,
7QRS
,
7QTU
,
7QSB
,
1X5Q
,
1UJU
,
7QS8
,
2W4F
,
5VWI
,
4WYT
,
6XA6
,
7QTO
,
7QRT
,
8B9T
,
4WYU
,
5VWC
,
1WHA
,
6MTU
,
6MS1
,
6MTV
,
5VWK
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.936
21
UniProt:P23508 CRCM
0.863
15
UniProt:P03126 VE6
0.855
9
UniProt:Q15349 RPS6KA2
7
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
(R-HSA-444290)
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619984)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619869)
p-T356,S360,T570-RPS6KA2 [cytosol]
(R-HSA-9619955)
RPS6KA2 [cytosol]
(R-HSA-444252)
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
(R-HSA-199871)
RPS6KA2 [nucleoplasm]
(R-HSA-199861)
0.769
9
UniProt:P25100 ADRA1D
1
ADRA1D [plasma membrane]
(R-HSA-390680)
0.76
19
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.744
7
UniProt:P53778 MAPK12
3
MAPK12 [cytosol]
(R-HSA-171025)
p-T183,Y185-MAPK12 [cytosol]
(R-HSA-171021)
MAPK12 [nucleoplasm]
(R-HSA-448833)
0.72
6
UniProt:Q9UDY2 TJP2
4
TJP2 [plasma membrane]
(R-HSA-351862)
TJP2(?-?) [plasma membrane]
(R-HSA-351897)
TJP2 [cytosol]
(R-HSA-2064412)
TJP2 [nucleoplasm]
(R-HSA-2064410)
0.714
8
UniProt:P06463 VE6
0.704
4
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.697
5
UniProt:Q99569 PKP4
2
PKP4 [cornified envelope]
(R-HSA-8847721)
PKP4 [plasma membrane]
(R-HSA-6814401)
0.684
4
UniProt:P33402 GUCY1A2
1
GUCY1A2 [cytosol]
(R-HSA-391996)
0.684
6
UniProt:O60346 PHLPP1
1
PHLPP1 [cytosol]
(R-HSA-199421)
0.669
4
UniProt:P49761 CLK3
0.643
3
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.643
6
UniProt:Q15418 RPS6KA1
7
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
0.611
3
UniProt:A6NIM6 S15A5
0.609
2
UniProt:Q7Z628 NET1
1
NET1 [cytosol]
(R-HSA-3006799)
0.609
2
UniProt:Q9P0K1 ADAM22
1
ADAM22 [plasma membrane]
(R-HSA-5678678)
0.609
3
UniProt:P48050 KCNJ4
1
KCNJ4 [plasma membrane]
(R-HSA-975336)
0.609
2
UniProt:Q14500 KCNJ12
1
KCNJ12 [plasma membrane]
(R-HSA-975282)
0.609
2
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.609
2
UniProt:Q9UQB3 CTND2
0.609
2
UniProt:Q5VV41 ARHGEF16
1
ARHGEF16 [cytosol]
(R-HSA-2976623)
0.59
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [nucleoplasm]
(R-HSA-1629775)
WWTR1 [cytosol]
(R-HSA-1629773)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
0.59
3
UniProt:P16473 TSHR
1
TSHR [plasma membrane]
(R-HSA-391371)
0.581
3
UniProt:P06427 VE6
0.573
3
UniProt:P24835 VE6
0.573
2
UniProt:P48065 SLC6A12
1
SLC6A12 [plasma membrane]
(R-HSA-351969)
0.573
2
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.571
2
UniProt:Q86X45 DAA11
0.564
2
UniProt:Q9C0D5 TANC1
0.558
4
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.558
2
UniProt:Q15654 TRIP6
0.557
5
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.527
2
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.527
3
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.527
5
UniProt:Q9NWS9 ZNF446
1
ZNF446 [nucleoplasm]
(R-HSA-1247863)
0.527
4
UniProt:Q9QXA3 Q9QXA3
0.524
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
10
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.463
2
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