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Table of Contents
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SCRIB [cytosol]
Stable Identifier
R-HSA-4608858
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CRIB, KIAA0147, LAP4, SCRB1, VARTUL
Locations in the PathwayBrowser for interactor UniProt:O60346
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)
SCRIB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14160 SCRIB
Gene Names
SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Chain
chain:1-1630
Reference Genes
BioGPS Gene:23513 SCRIB
COSMIC (genes):SCRIB SCRIB
CTD Gene:23513 SCRIB
dbSNP Gene:23513 SCRIB
ENSEMBL:ENSG00000180900 SCRIB
HGNC:30377 SCRIB
KEGG Gene (Homo sapiens):23513 SCRIB
Monarch:23513 SCRIB
NCBI Gene:23513 SCRIB
OMIM:607733 SCRIB
UCSC:Q14160 SCRIB
Reference Transcript
RefSeq:NM_182706.4 SCRIB
RefSeq:NM_015356.4 SCRIB
Other Identifiers
0001580452
0004120537
0005570152
11721210_a_at
11721211_x_at
11744785_x_at
17082263
212556_at
23513
3157752
3157753
3157754
3157755
3157756
3157759
3157761
3157762
3157763
3157764
3157766
3157767
3157768
3157769
3157772
3157776
3157777
3157778
3157781
3157782
3157783
3157786
3157787
3157788
3157790
3157791
3157792
3157794
3157795
3157796
3157797
3157798
3157800
3157801
3157802
3157803
3157804
3157805
3157806
3157807
3157808
3157809
3157810
3157811
3157812
3157813
3157814
3157816
34743_at
8153497
81576_at
A_23_P159039
D63481_at
GO:0000278
GO:0000902
GO:0001768
GO:0001772
GO:0001843
GO:0001921
GO:0002093
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0006810
GO:0006950
GO:0007049
GO:0007155
GO:0007267
GO:0007275
GO:0008104
GO:0008150
GO:0008219
GO:0008283
GO:0008328
GO:0009790
GO:0014069
GO:0015031
GO:0016020
GO:0016032
GO:0016080
GO:0016192
GO:0016323
GO:0016331
GO:0016477
GO:0021747
GO:0030027
GO:0030054
GO:0030154
GO:0030683
GO:0030859
GO:0031252
GO:0032729
GO:0032991
GO:0034750
GO:0035089
GO:0035748
GO:0039563
GO:0039564
GO:0040011
GO:0042060
GO:0042734
GO:0042995
GO:0043065
GO:0043113
GO:0043226
GO:0043615
GO:0044291
GO:0044403
GO:0045197
GO:0045202
GO:0045211
GO:0045296
GO:0045930
GO:0046007
GO:0048488
GO:0048646
GO:0048856
GO:0048870
GO:0050918
GO:0060088
GO:0060561
GO:0060603
GO:0070062
GO:0071896
GO:0090630
GO:0097060
GO:0097120
GO:0098609
GO:0098793
GO:0098794
GO:0098887
GO:0098968
GO:0098978
GO:0099147
Hs.239784.0.S1_3p_at
Hs.239784.0.S1_3p_x_at
ILMN_1695181
ILMN_1726516
ILMN_2324029
PH_hs_0020510
TC08001732.hg
Participant Of
input
SCRIB is required for asymmetric membrane localization of VANGL2
hasComponent
VANGL2:SCRIB [plasma membrane]
Cross References
RefSeq
NP_056171.3
,
NP_874365.3
OpenTargets
ENSG00000180900
HPA
ENSG00000180900-SCRIB
GeneCards
Q14160
Ensembl
ENSP00000322938
,
ENSP00000366756
,
ENST00000320476
,
ENST00000377533
,
ENSG00000180900
,
ENST00000356994
,
ENSP00000349486
PRO
Q14160
Orphanet
24888
PDB
1WHA
,
6MYE
,
5VWI
,
6EEY
,
6MS1
,
4WYU
,
6MTV
,
5VWC
,
4WYT
,
1UJU
,
6ESP
,
6MTU
,
6MYF
,
5VWK
,
2W4F
,
1X5Q
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.901
17
UniProt:P23508 CRCM
0.821
14
UniProt:P03126 VE6
0.811
8
UniProt:Q15349 RPS6KA2
7
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
(R-HSA-199871)
RPS6KA2 [nucleoplasm]
(R-HSA-199861)
RPS6KA2 [cytosol]
(R-HSA-444252)
p-T356,S360,T570-RPS6KA2 [cytosol]
(R-HSA-9619955)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
(R-HSA-444290)
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619984)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619869)
0.769
9
UniProt:P25100 ADRA1D
1
ADRA1D [plasma membrane]
(R-HSA-390680)
0.76
19
UniProt:P53778 MAPK12
3
MAPK12 [cytosol]
(R-HSA-171025)
MAPK12 [nucleoplasm]
(R-HSA-448833)
p-T183,Y185-MAPK12 [cytosol]
(R-HSA-171021)
0.72
6
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
0.697
5
UniProt:P33402 GUCY1A2
1
GUCY1A2 [cytosol]
(R-HSA-391996)
0.684
6
UniProt:Q99569 PKP4
2
PKP4 [plasma membrane]
(R-HSA-6814401)
PKP4 [cornified envelope]
(R-HSA-8847721)
0.684
4
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.669
4
UniProt:Q9UDY2 TJP2
4
TJP2 [nucleoplasm]
(R-HSA-2064410)
TJP2 [cytosol]
(R-HSA-2064412)
TJP2 [plasma membrane]
(R-HSA-351862)
TJP2(?-?) [plasma membrane]
(R-HSA-351897)
0.625
6
UniProt:Q15418 RPS6KA1
7
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.611
3
UniProt:Q9UQB3 CTND2
0.609
2
UniProt:P06463 VE6
0.609
3
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.609
2
UniProt:Q14500 KCNJ12
1
KCNJ12 [plasma membrane]
(R-HSA-975282)
0.609
2
UniProt:P48050 KCNJ4
1
KCNJ4 [plasma membrane]
(R-HSA-975336)
0.609
2
UniProt:Q9P0K1 ADAM22
1
ADAM22 [plasma membrane]
(R-HSA-5678678)
0.609
3
UniProt:Q7Z628 NET1
1
NET1 [cytosol]
(R-HSA-3006799)
0.609
2
UniProt:A6NIM6 S15A5
0.609
2
UniProt:Q5VV41 ARHGEF16
1
ARHGEF16 [cytosol]
(R-HSA-2976623)
0.59
2
UniProt:Q9GZV5 WWTR1
3
WWTR1 [cytosol]
(R-HSA-1629773)
WWTR1 [nucleoplasm]
(R-HSA-1629775)
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
0.59
3
UniProt:O60346 PHLPP1
1
PHLPP1 [cytosol]
(R-HSA-199421)
0.589
2
UniProt:P16473 TSHR
1
TSHR [plasma membrane]
(R-HSA-391371)
0.581
3
UniProt:P48065 SLC6A12
1
SLC6A12 [plasma membrane]
(R-HSA-351969)
0.573
2
UniProt:P27361 MAPK3
6
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
0.558
2
UniProt:Q9C0D5 TANC1
0.558
4
UniProt:Q15654 TRIP6
0.557
5
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9QXA3 Q9QXA3
0.524
5
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.463
2
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