Reactome | SMURF1/2 are recruited to the DVL2:PARD6A complex

SMURF1/2 are recruited to the DVL2:PARD6A complex

Stable Identifier

R-HSA-4608854

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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SMURF1/2 are recruited to the DVL2:PARD6A complex

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The E3 ubiquitin ligases SMURF1/2 are recruited to the DVL:PARD6A complex after WNT5A stimulation. Recruitment depends on DVL2 phosphorylation and is mediated by the DEP domain of DVL2 that is important for PCP signaling (Narimatsu et al, 2009; Boutros et al, 1998). Smurf1 and 2 mutant mice show defects in convergent extension and neural tube closure, as well as misorientation of sensory hairs in the inner ear, phenotypes consistent with a role for SMURFs in the PCP pathway (Narimatsu et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19379695	Regulation of planar cell polarity by Smurf ubiquitin ligases Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL	Cell	2009
9674432	Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling Boutros, M, Paricio, N, Strutt, DI, Mlodzik, M	Cell	1998