SUMOylation of MDC1 with SUMO1

Stable Identifier
R-HSA-4570554
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SUMOylation of MDC1 with SUMO1
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MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).

Literature References
PubMed ID Title Journal Year
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z

EMBO J. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]
Physical Entity
SUMO1:C93-UBE2I [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
SUMOylation of MDC1 with SUMO1 (Bos taurus)
SUMOylation of MDC1 with SUMO1 (Caenorhabditis elegans)
SUMOylation of MDC1 with SUMO1 (Canis familiaris)
SUMOylation of MDC1 with SUMO1 (Danio rerio)
SUMOylation of MDC1 with SUMO1 (Dictyostelium discoideum)
SUMOylation of MDC1 with SUMO1 (Mus musculus)
SUMOylation of MDC1 with SUMO1 (Rattus norvegicus)
SUMOylation of MDC1 with SUMO1 (Schizosaccharomyces pombe)
Authored
May, B  (2013-09-19)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-21)
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