MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).
Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H
SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]
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