SUMOylation of MDC1 with SUMO2,3

Stable Identifier
R-HSA-4570553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of MDC1 with SUMO2,3
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MDC1 is SUMOylated at lysine-1840 with SUMO2,3 (Luo et al. 2012, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation is required for degradation of MDC1. SUMOylation of MDC1 is required for recruitment of RNF4 (Yin et al. 2012), which is believed to ubiquitinylate MDC1, resulting in degradation of MDC1.
Literature References
PubMed ID Title Journal Year
22661230 SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Seifert, A, Golebiowski, F, Maure, JF, Hay, RT, Chua, JS, Yin, Y

Genes Dev. 2012
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H

EMBO J. 2012
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Catalyst Activity

SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]

Physical Entity
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of MDC1 with SUMO2,3 (Bos taurus)
SUMOylation of MDC1 with SUMO2,3 (Drosophila melanogaster)
SUMOylation of MDC1 with SUMO2,3 (Mus musculus)
SUMOylation of MDC1 with SUMO2,3 (Rattus norvegicus)
SUMOylation of MDC1 with SUMO2,3 (Sus scrofa)
SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-09-19)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-21)
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