Reactome | SUMOylation of MDC1 with SUMO2,3

SUMOylation of MDC1 with SUMO2,3

Stable Identifier

R-HSA-4570553

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MDC1 is SUMOylated at lysine-1840 with SUMO2,3 (Luo et al. 2012, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation is required for degradation of MDC1. SUMOylation of MDC1 is required for recruitment of RNF4 (Yin et al. 2012), which is believed to ubiquitinylate MDC1, resulting in degradation of MDC1.

Literature References

PubMed ID	Title	Journal	Year
22661230	SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Yin, Y, Seifert, A, Chua, JS, Maure, JF, Golebiowski, F, Hay, RT	Genes Dev.	2012
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
22635276	Sumoylation of MDC1 is important for proper DNA damage response Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z	EMBO J.	2012