SUMO2,3-K1840-MDC1 [nucleoplasm]

Stable Identifier
R-HSA-4570473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Mediator of DNA damage checkpoint protein 1, MDC1_HUMAN
SUMO2,3-K1840-MDC1 [nucleoplasm] icon
Locations in the PathwayBrowser for interactor UniProt:P16104 H2AX
Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z

EMBO J. 2012
External Reference Information
External Reference
Gene Names
MDC1, KIAA0170, NFBD1
Chain
chain:1-2089
Other Identifiers
0006200402
11748150_a_at
11748405_a_at
11751800_a_at
11758138_s_at
17016966
17026706
17028857
17031635
17034090
17036357
17039133
17041700
203061_s_at
203062_s_at
2948565
2948566
2948567
2948568
2948569
2948570
2948571
2948572
2948574
2948575
2948577
2948578
2948579
2948580
2948581
2948582
2948583
2948584
2948586
32661_s_at
32662_at
8124813
8178404
9656
A_23_P19455
D79992_at
GE87930
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005925
GO:0006259
GO:0006281
GO:0006303
GO:0006950
GO:0006974
GO:0007049
GO:0008022
GO:0008150
GO:0016604
GO:0031573
GO:0034641
GO:0042802
GO:0043226
GO:0070975
Hs.277585.0.A1_3p_a_at
ILMN_1814122
PH_hs_0020142
TC06001507.hg
TC6_apd_hap1000077.hg
TC6_cox_hap2000141.hg
TC6_dbb_hap3000130.hg
TC6_mann_hap4000119.hg
TC6_mcf_hap5000120.hg
TC6_qbl_hap6000131.hg
TC6_ssto_hap7000121.hg
g7661965_3p_a_at
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840
Coordinate
1840
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Interactors (14)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O60934 NBN  3 0.968 33
 UniProt:P16104 H2AX  7 0.965 21
 UniProt:O76064 RNF8  1 0.725 11
 UniProt:Q92878 RAD50  1 0.69 9
 UniProt:P49959 MRE11  2 0.69 9
 UniProt:P38398 BRCA1  5 0.648 4
 UniProt:Q13315 ATM  5 0.623 3
 UniProt:O96028-1 NSD2      0.602 3
 UniProt:O96028 NSD2  2 0.591 3
 UniProt:Q12888 TP53BP1  3 0.577 4
 UniProt:Q14676 MDC1  6 0.564 2
 UniProt:Q9BXW9 FANCD2  3 0.527 2
 UniProt:O76064-1 RNF8      0.524 2
 UniProt:Q06609 RAD51  2 0.524 3
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