SUMOylation of NOP58 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOP58 (NOP5) is SUMOylated at lysine-467 and lysine-497 with SUMO1 (Matafora et al. 2009, Westman et al. 2010, Westman and Lamond 2011,Impens et al. 2014). SUMOylation is required for binding of snoRNAs by NOP58.

Literature References
PubMed ID Title Journal Year
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A

Mol. Cell Proteomics 2009
12196509 Proteomic analysis of the mammalian nuclear pore complex

Matunis, MJ, Cronshaw, JM, Chait, BT, Zhang, W, Krutchinsky, AN

J Cell Biol 2002
20797632 A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58

Lam, YW, Lamond, AI, Bertrand, E, Westman, BJ, Verheggen, C, Hutten, S

Mol. Cell 2010
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
21647297 A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics

Lamond, AI, Westman, BJ

Nucleus 2011
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
Cite Us!