CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3

Stable Identifier
R-HSA-4570463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3
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CBX4 (Pc2) in the PRC1 complex SUMOylates CETN2 at an unknown residue with SUMO2,3 (Klein and Nigg 2009). SUMOylation of CETN2 enhances its nuclear localization. Interaction with XPC is also required for nuclear localization of CETN2.

Literature References
PubMed ID Title Journal Year
19706679 SUMO-dependent regulation of centrin-2

Nigg, EA, Klein, UR

J. Cell. Sci. 2009
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Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Physical Entity
PRC1 complex [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Danio rerio)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-09-19)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-21)
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