CDKN2A (p14-ARF) SUMOylates WRN with SUMO1

Stable Identifier
R-HSA-4568846
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDKN2A (p14-ARF) SUMOylates WRN with SUMO1
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CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus.

Literature References
PubMed ID Title Journal Year
15355988 p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Saville, MK, Lane, DP, Sparks, A, Prescott, AR, Xirodimas, DP, Woods, YL

J. Biol. Chem. 2004
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Catalyst Activity

SUMO transferase activity of p14ARF [nucleoplasm]

Physical Entity
p14ARF [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Authored
May, B  (2013-09-14)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-19)
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