AP-1 stimulates IL1A transcription

Stable Identifier
R-HSA-4568740
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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AP-1 stimulates IL1A transcription
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The AP-1 complex (FOS:JUN) binds IL1A promoter and stimulates IL1A transcription (Bailly et al. 1996 Alheim et al. 1996, Burleson et al. 1996, Huang et al. 1999, Niu et al. 2004, Moerman-Herzog and Barger 2012, Murakami et al. 2013).
Literature References
PubMed ID Title Journal Year
8884985 Dermatotoxic chemical stimulate of c-jun and c-fos transcription and AP-1 DNA binding in human keratinocytes

Germolec, DR, Simeonova, PP, Burleson, FG, Luster, MI

Res. Commun. Mol. Pathol. Pharmacol. 1996
23846687 N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1? by Human Gastric Cancer Cells

Mukaida, N, Murakami, Y, Watari, K, Kuwano, M, Abe, H, Ono, M, Ureshino, H, Izumi, H, Kawahara, A, Shibata, T, Uba, M

J. Biol. Chem. 2013
14679213 Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells

Niu, J, Peng, B, Li, Z, Chiao, PJ

J. Biol. Chem. 2004
22634325 A polymorphism in the upstream regulatory region of the interleukin-1? gene confers differential binding by transcription factors of the AP-1 family

Moerman-Herzog, AM, Barger, SW

Life Sci. 2012
10432220 Serotonin-inducible transcription of interleukin-1alpha in uterine smooth muscle cells requires an AP-1 site: cloning and partial characterization of the rat IL-1alpha promoter

Jeffrey, JJ, Huang, TT, Lan, L, Wilcox, BD, Vinci, JM

Mol. Cell. Endocrinol. 1999
8939459 An AP-1 site is involved in the NGF induction of IL-1 alpha in PC12 cells

McDowell, TL, Duff, GW, Bartfai, T, Symons, JA, Alheim, K

Neurochem. Int. 1996
8688489 The transcription factor AP-1 binds to the human interleukin 1 alpha promoter

Israël, N, Gougerot-Pocidalo, MA, Fay, M, Bailly, S

Eur. Cytokine Netw. 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-2S-JUN:p-2S,2T-FOS:IL1A gene [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-cJUN:p-2S,2T-cFOS [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-09-16)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-09-16)
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