Reactome | AcK13-HIST1H2BB [nucleoplasm]

AcK13-HIST1H2BB [nucleoplasm]

Stable Identifier

R-HSA-4568629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK13-replicative histone H2B [nucleoplasm] (Homo sapiens)
        
        Ack13-replicative histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HCMV Infection (Homo sapiens)
      - HCMV Early Events (Homo sapiens)
        
        Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
      - HCMV Late Events (Homo sapiens)
        
        Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33778 H2BC3

Gene Names

H2BC3, H2BFF, HIST1H2BB

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:3018 H2BC3

CTD Gene:3018 H2BC3

dbSNP Gene:3018 H2BC3

ENSEMBL:ENSG00000276410 HIST1H2BB

ENSEMBL:ENSG00000276410.4 H2BC3

HGNC:4751 H2BC3

KEGG Gene (Homo sapiens):3018 H2BC3

Monarch:3018 H2BC3

NCBI Gene:3018 H2BC3

OMIM:602803 H2BC3

UCSC:P33778 H2BC3

Reference Transcript

RefSeq:NM_021062.2 H2BC3

Other Identifiers

11738961_at

11738962_x_at

17016369

208547_PM_at

208547_at

2946226

2946227

3018

8124394

A_23_P111054

GE82583

GO:0000781

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

HMNXSV003019557

ILMN_1750180

PH_hs_0029507

TC06001344.hg

g10800139_3p_at

g10800139_3p_x_at

Participates

as a member of

Other forms of this molecule

Ub-HIST1H2BB [nucleoplasm]

AcK-HIST1H2BB [nucleoplasm]

HIST1H2BB [extracellular region]

AcK21-HIST1H2BB [nucleoplasm]

AcK16-HIST1H2BB [nucleoplasm]

AcK6-HIST1H2BB [nucleoplasm]

Ub-121-HIST1H2BB [nucleoplasm]

HIST1H2BB [nucleoplasm]

Inferred To

H2B-V [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

AcK13-HIST1H2BB [nucleoplasm] (Bos taurus)

AcK13-HIST1H2BB [nucleoplasm] (Canis familiaris)

AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

h2bc14 [nucleoplasm] (Xenopus tropicalis)

H2B-I [nucleoplasm] (Gallus gallus)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

si:ch211-113a14.29 [nucleoplasm] (Danio rerio)

Modified Residues

Name

N6-acetyl-L-lysine at 13

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_066406.1

OpenTargets

ENSG00000276410

HPA

ENSG00000276410-H2BC3

GeneCards

P33778

Ensembl

ENST00000615966, ENSP00000482674, ENSG00000276410

PRO

P33778

Pharos - Targets

P33778

PDB

3X1U, 3X1S

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