Reactome | AcK13-HIST1H2BB [nucleoplasm]

AcK13-HIST1H2BB [nucleoplasm]

Stable Identifier

R-HSA-4568629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK13-replicative histone H2B [nucleoplasm] (Homo sapiens)
        
        Ack13-replicative histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1/2 containing-complexes deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BB [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33778 HIST1H2BB

Gene Names

HIST1H2BB, H2BFF

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:3018 HIST1H2BB

COSMIC (genes):HIST1H2BB HIST1H2BB

CTD Gene:3018 HIST1H2BB

dbSNP Gene:3018 HIST1H2BB

ENSEMBL:ENSG00000276410 HIST1H2BB

ENSEMBL_homo_sapiens_GENE:ENSG00000276410 HIST1H2BB

HGNC:4751 HIST1H2BB

KEGG Gene (Homo sapiens):3018 HIST1H2BB

Monarch:3018 HIST1H2BB

NCBI Gene:3018 HIST1H2BB

OMIM:602803 HIST1H2BB

UCSC:P33778 HIST1H2BB

Reference Transcript

RefSeq:NM_021062.2 HIST1H2BB

Other Identifiers

0002940021

11738961_at

11738962_x_at

17016369

208547_at

2946226

2946227

3018

3X1S

3X1U

42205

43013

48671

8124394

A_23_P111054

AAH96728

AAN06685

AF531285

BC096728

CAA40406

CCDS4575

ENSG00000276410

ENSP00000482674

ENST00000615966

EntrezGene:3018

g10800139_3p_at

g10800139_3p_x_at

GE82583

GO:0000228

GO:0000784

GO:0000786

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006334

GO:0006464

GO:0008150

GO:0016567

GO:0022607

GO:0032991

GO:0043226

GO:0046982

GO:0051276

GO:0065003

HGNC:4751

HIST1H2BB

HIST1H2BB-201

HPA042205

HPA043013

HPA048671

ILMN_1750180

IPR000558

IPR007125

IPR009072

MIM:602803

NM_021062

NP_066406

PF00125

PH_hs_0029507

PR00621

SM00427

TC06001344.hg

uc003nfu.4

UPI0000001BD2

X57127

Participant Of

hasMember

Other forms of this molecule

HIST1H2BB [extracellular region]

Ub-HIST1H2BB [nucleoplasm]

AcK-HIST1H2BB [nucleoplasm]

AcK21-HIST1H2BB [nucleoplasm]

AcK16-HIST1H2BB [nucleoplasm]

AcK6-HIST1H2BB [nucleoplasm]

Ub-121-HIST1H2BB [nucleoplasm]

HIST1H2BB [nucleoplasm]

Inferred To

AcK13-HIST1H2BB [nucleoplasm] (Arabidopsis thaliana)

AcK13-HIST1H2BB [nucleoplasm] (Bos taurus)

AcK13-HIST1H2BB [nucleoplasm] (Caenorhabditis elegans)

AcK13-HIST1H2BB [nucleoplasm] (Canis familiaris)

AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

AcK13-HIST1H2BB [nucleoplasm] (Dictyostelium discoideum)

AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

AcK13-HIST1H2BB [nucleoplasm] (Oryza sativa)

AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

AcK13-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

AcK13-HIST1H2BB [nucleoplasm] (Schizosaccharomyces pombe)

AcK13-HIST1H2BB [nucleoplasm] (Sus scrofa)

AcK13-HIST1H2BB [nucleoplasm] (Taeniopygia guttata)

AcK13-HIST1H2BB [nucleoplasm] (Xenopus tropicalis)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Arabidopsis thaliana)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Caenorhabditis elegans)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Oryza sativa)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Taeniopygia guttata)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

N6-acetyl-L-lysine at 13

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_066406.1

OpenTargets

ENSG00000276410

GeneCards

P33778

DOCK Blaster

3X1S, 3X1U

PRO

P33778

PDB

3X1S, 3X1U