PIAS4 SUMOylates PARP1 with SUMO2,3

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO2,3 in response to heat shock (Martin et al. 2009, Lamoliatte et al. 2013, Hendriks et al. 2014, Tammsalu et al. 2014). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). SUMOylation of PARP1 is required for full activation of the HSP70.1 promoter (Martin et al. 2009).

Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
19779455 PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

Martin, N, Schwamborn, K, Schreiber, V, Werner, A, Guillier, C, Zhang, XD, Bischof, O, Seeler, JS, Dejean, A

EMBO J. 2009
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
23750026 Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions

Lamoliatte, F, Bonneil, E, Durette, C, Caron-Lizotte, O, Wildemann, D, Zerweck, J, Wenshuk, H, Thibault, P

Mol. Cell Proteomics 2013
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
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