CBX4 SUMOylates CBX4 in PRC1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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CBX4 in Polycomb Repressive Complex 1 (PRC1) autoSUMOylates with SUMO1 (Kagey et al.2005, Roscic et al. 2006, Merrill et al. 2010). As inferred from mouse homologs, SUMOylation of CBX4 appears to be essential for recruitment of the PRC1 complex to histone H3 trimethylated at lysine-27 (H3K27me3) (Kang et al. 2010).
Literature References
PubMed ID Title Journal Year
17018294 Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2

Lüdi, KS, Möller, A, Calzado, MA, Roscic, A, Gresko, E, Renner, F, Schmitz, ML, Wimmer, VC

Mol. Cell 2006
15592428 Multiple activities contribute to Pc2 E3 function

Melhuish, TA, Wotton, D, Powers, SE, Kagey, MH

EMBO J. 2005
20098713 A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Yang, SH, Melhuish, TA, Merrill, JC, Sharrocks, AD, Wotton, D, Kagey, MH

PLoS ONE 2010
20417598 SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development

Kang, X, Yeh, ET, Zou, Y, Schwartz, RJ, Cheng, J, Zuo, Y, Wang, Q, Qi, Y

Mol. Cell 2010
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Orthologous Events
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