CBX4 SUMOylates BMI1 in PRC1 with SUMO1

Stable Identifier
R-HSA-4551655
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CBX4 SUMOylates BMI1 in PRC1 with SUMO1
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CBX4 SUMOylates BMI1 in Polycomb Repressive Complex 1 (PRC1) at lysine-88 (Ismail et al. 2012). SUMOylation of BMI1 is necessary for its accumulation at sites of DNA damage. CBX4 directly binds poly(ADP-ribose) synthesized by PARP1 at sites of damage.
Literature References
PubMed ID Title Journal Year
22402492 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage

Ismail, IH, Gagné, JP, Caron, MC, McDonald, D, Xu, Z, Masson, JY, Poirier, GG, Hendzel, MJ

Nucleic Acids Res. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Physical Entity
PRC1 complex [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Bos taurus)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-09-13)
Reviewed
Lu, J  (2017-01-22)
Matunis, MJ  (2017-01-22)
Yang, WC  (2017-01-22)
Created
May, B  (2013-09-14)
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