PIAS1,3 SUMOylates NR5A1 with SUMO2

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS1,3 SUMOylate NR5A1 (Steroidogenic factor 1, SF1, SF-1) at lysine-119 and lysine-194 with SUMO2 (Chen et al. 2004, Komatsu et al. 2004, Suda et al. 2011). SUMOylation reduces synergistic activation of SOX9 by NR5A1.

Literature References
PubMed ID Title Journal Year
15192080 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9

Komatsu, T, Mizusaki, H, Mukai, T, Ogawa, H, Baba, D, Shirakawa, M, Hatakeyama, S, Nakayama, KI, Yamamoto, H, Kikuchi, A, Morohashi, K

Mol. Endocrinol. 2004
21467194 Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1

Suda, N, Shibata, H, Kurihara, I, Ikeda, Y, Kobayashi, S, Yokota, K, Murai-Takeda, A, Nakagawa, K, Oya, M, Murai, M, Rainey, WE, Saruta, T, Itoh, H

Endocrinology 2011
15192092 SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1)

Chen, WY, Lee, WC, Hsu, NC, Huang, F, Chung, BC

J. Biol. Chem. 2004
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Orthologous Events
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