Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
Stable Identifier
R-HSA-4546382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Steroidogenic factor 1, STF1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13285 NR5A1
Gene Names
NR5A1, AD4BP, FTZF1, SF1
Chain
chain:1-461
Reference Genes
BioGPS Gene:2516 NR5A1
COSMIC (genes):NR5A1 NR5A1
CTD Gene:2516 NR5A1
dbSNP Gene:2516 NR5A1
ENSEMBL:ENSG00000136931 NR5A1
HGNC:7983 NR5A1
KEGG Gene (Homo sapiens):2516 NR5A1
Monarch:2516 NR5A1
NCBI Gene:2516 NR5A1
OMIM:184757 NR5A1
UCSC:Q13285 NR5A1
Reference Transcript
RefSeq:NM_004959.4 NR5A1
RefSeq:XM_005251871.3 NR5A1
RefSeq:XM_011518455.2 NR5A1
Other Identifiers
0005050685
11731105_at
11731106_at
17098293
210333_at
2516
3225059
3225060
3225061
3225070
3225075
3225076
3225077
3225078
3225089
3225090
32447_at
8164077
83680_at
83682_g_at
A_23_P216915
D88155_s_at
GE546293
GO:0000003
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001553
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0004879
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006629
GO:0007165
GO:0007530
GO:0007538
GO:0007568
GO:0008150
GO:0008270
GO:0008289
GO:0008584
GO:0008585
GO:0009058
GO:0009755
GO:0009888
GO:0010259
GO:0010628
GO:0019899
GO:0022414
GO:0030154
GO:0030238
GO:0030325
GO:0030522
GO:0032991
GO:0034641
GO:0042445
GO:0043167
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0050810
GO:0051457
GO:0090575
GO:0097210
GO:0097720
GO:1990837
GO:2000020
GO:2000195
HMNXSV003027026
HMNXSV003048722
ILMN_1799675
ILMN_1815320
PH_hs_0009492
TC09001579.hg
U76388_at
g2052387_3p_at
g2052387_3p_x_at
Participates
as an output of
PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
Other forms of this molecule
NR5A1 [nucleoplasm]
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
Inferred To
nhr-258 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Danio rerio)
nr5a5 [nucleoplasm]
(Danio rerio)
nhr-277 [nucleoplasm]
(Caenorhabditis elegans)
nr5a1a [nucleoplasm]
(Danio rerio)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Xenopus tropicalis)
nr5a1b [nucleoplasm]
(Danio rerio)
Nr5a1 [nucleoplasm]
(Mus musculus)
Nr5a1 [nucleoplasm]
(Rattus norvegicus)
nhr-38 [nucleoplasm]
(Caenorhabditis elegans)
nr5a2 [nucleoplasm]
(Danio rerio)
NR5A1 [nucleoplasm]
(Gallus gallus)
nhr-25 [nucleoplasm]
(Caenorhabditis elegans)
nhr-3 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 119
Coordinate
119
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 194
Coordinate
194
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_004950.2
,
XP_011516757.1
,
XP_005251928.1
Guide to Pharmacology - Targets
632
OpenTargets
ENSG00000136931
ZINC - Substances
STF1_HUMAN
ZINC target
Q13285
PRO
Q13285
PDB
4QJR
,
4QK4
,
7KHT
,
1YOW
,
1ZDT
HPA
ENSG00000136931-NR5A1
GeneCards
Q13285
Ensembl
ENST00000373588
,
ENSP00000362690
,
ENSG00000136931
Pharos - Targets
Q13285
Orphanet
17744
ZINC - Predictions - Purchasable
STF1_HUMAN
HMDB Protein
HMDBP02951
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51843 NR0B1
0.805
9
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
3
UniProt:Q53TS8 C2CD6
0.556
3
UniProt:Q9NPJ4 PNRC2
1
PNRC2 [cytosol]
(R-HSA-8879146)
0.488
2
IntAct:EBI-9981598 3BHS2
0.462
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text