Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
Stable Identifier
R-HSA-4546382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Steroidogenic factor 1, STF1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13285 NR5A1
Gene Names
NR5A1, AD4BP, FTZF1, SF1
Chain
chain:1-461
Reference Genes
BioGPS Gene:2516 NR5A1
COSMIC (genes):NR5A1 NR5A1
COSMIC (genes):SF1 NR5A1
CTD Gene:2516 NR5A1
dbSNP Gene:2516 NR5A1
ENSEMBL:ENSG00000136931 NR5A1
HGNC:7983 NR5A1
KEGG:hsa:2516 NR5A1
Monarch:2516 NR5A1
NCBI Gene:2516 NR5A1
OMIM:184757 NR5A1
UCSC:Q13285 NR5A1
Reference Transcript
RefSeq:XM_011518455.2 NR5A1
RefSeq:NM_004959.4 NR5A1
RefSeq:XM_005251871.3 NR5A1
Other Identifiers
11731105_at
11731106_at
17098293
210333_PM_at
210333_at
2516
3225059
3225060
3225061
3225070
3225075
3225076
3225077
3225078
3225089
3225090
32447_at
8164077
83680_at
83682_g_at
A_23_P216915
D88155_s_at
GE546293
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001221
GO:0001553
GO:0003677
GO:0003682
GO:0003700
GO:0004879
GO:0005515
GO:0005543
GO:0005634
GO:0005654
GO:0005829
GO:0006355
GO:0006357
GO:0007530
GO:0007538
GO:0008270
GO:0008289
GO:0008584
GO:0008585
GO:0009755
GO:0009888
GO:0010628
GO:0019899
GO:0022414
GO:0030154
GO:0030238
GO:0030325
GO:0030522
GO:0033327
GO:0042445
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0050810
GO:0051457
GO:0060008
GO:0060089
GO:0090575
GO:0140110
GO:1990837
GO:2000020
GO:2000195
HMNXSV003027026
HMNXSV003048722
ILMN_1815320
PH_hs_0009492
TC09001579.hg
U76388_at
g2052387_3p_at
g2052387_3p_x_at
Participates
as an output of
PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
Other forms of this molecule
NR5A1 [nucleoplasm]
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
Inferred To
nhr-258 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Danio rerio)
nhr-38 [nucleoplasm]
(Caenorhabditis elegans)
nhr-277 [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Bos taurus)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Danio rerio)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Gallus gallus)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Mus musculus)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Sus scrofa)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(Xenopus tropicalis)
nhr-25 [nucleoplasm]
(Caenorhabditis elegans)
nhr-3 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 119
Coordinate
119
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 194
Coordinate
194
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
XP_011516757.1
,
XP_005251928.1
,
NP_004950.2
Guide to Pharmacology - Targets
632
OpenTargets
ENSG00000136931
ENSEMBL
ENSP00000362690
,
ENST00000373588
ZINC - Substances
STF1_HUMAN
ZINC target
Q13285
PRO
Q13285
GlyGen
Q13285
PDB
1ZDT
,
1YOW
,
8DAF
,
7KHT
,
4QJR
,
4QK4
HPA
ENSG00000136931-NR5A1
Pharos - Targets
Q13285
Orphanet
NR5A1
ZINC - Predictions - Purchasable
STF1_HUMAN
HMDB Protein
HMDBP02951
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51843 NR0B1
0.805
9
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.609
2
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
3
UniProt:Q53TS8 CTSRT
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
UniProt:Q13510 ASAH1
8
ASAH1(143-395) [lysosomal lumen]
(R-HSA-1606581)
ASAH1(22-142) [lysosomal lumen]
(R-HSA-1606608)
ASAH1(22-142) [ficolin-1-rich granule lumen]
(R-HSA-6801029)
ASAH1(143-395) [ficolin-1-rich granule lumen]
(R-HSA-6800880)
ASAH1(22-142) [extracellular region]
(R-HSA-6801046)
ASAH1(143-395) [extracellular region]
(R-HSA-6801047)
ASAH1(143-395) [tertiary granule lumen]
(R-HSA-6800907)
ASAH1(22-142) [tertiary granule lumen]
(R-HSA-6800886)
0.548
4
IntAct:EBI-9981687 STAR
0.527
2
UniProt:Q13510-2 Q135102
0.524
3
UniProt:Q9NPJ4 PNRC2
1
PNRC2 [cytosol]
(R-HSA-8879146)
0.488
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.483
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
UniProt:CYP17A1 ENSG00000148795
0.462
2
IntAct:EBI-9981598 3BHS2
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text