p-Y348-SYK dissociates

Stable Identifier
R-HSA-453183
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Structural and biophysical studies indicate that the adaptability of the Syk tandem SH2 domains is made possible by relatively weak interactions between the two SH2 domains and the flexibility of interdomain A (Zhang et al. 2008). A large proportion of phosphorylated Syk is released into the cytosol. One factor that has been proposed for modulating the interactions of Syk with the receptor ITAM is the phosphorylation of Syk on Y130 (Keshvara et al. 1997).

Literature References
PubMed ID Title Journal Year
8617742 Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine

Peters, JD, Furlong, MT, Asai, DJ, Harrison, ML, Geahlen, RL

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
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Created