Reactome | p-Y348-SYK dissociates

p-Y348-SYK dissociates

Stable Identifier

R-HSA-453183

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Structural and biophysical studies indicate that the adaptability of the Syk tandem SH2 domains is made possible by relatively weak interactions between the two SH2 domains and the flexibility of interdomain A (Zhang et al. 2008). A large proportion of phosphorylated Syk is released into the cytosol. One factor that has been proposed for modulating the interactions of Syk with the receptor ITAM is the phosphorylation of Syk on Y130 (Keshvara et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8617742	Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine Peters, JD, Asai, DJ, Furlong, MT, Geahlen, RL, Harrison, ML	J Biol Chem	1996