Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FOXA1 [nucleoplasm]
Stable Identifier
R-HSA-453074
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hepatocyte nuclear factor 3-alpha, FOXA1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q02809 PLOD1
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of axial mesoderm (Homo sapiens)
Expression of NOTO in axial mesoderm (Homo sapiens)
FOXA1 [nucleoplasm] (Homo sapiens)
Expression of SHH in axial mesoderm (Homo sapiens)
FOXA1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)
FOXA1 [nucleoplasm] (Homo sapiens)
FOXA1 and GATA3 bind TFF genes (Homo sapiens)
FOXA1 [nucleoplasm] (Homo sapiens)
FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
FOXA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55317 FOXA1
Gene Names
FOXA1, HNF3A, TCF3A
Chain
chain:1-472
Reference Genes
BioGPS Gene:3169 FOXA1
COSMIC (genes):FOXA1 FOXA1
CTD Gene:3169 FOXA1
dbSNP Gene:3169 FOXA1
ENSEMBL:ENSG00000129514 FOXA1
ENSEMBL_homo_sapiens_GENE:ENSG00000129514.8 FOXA1
HGNC:5021 FOXA1
KEGG Gene (Homo sapiens):3169 FOXA1
Monarch:3169 FOXA1
NCBI Gene:3169 FOXA1
OMIM:602294 FOXA1
UCSC:P55317 FOXA1
Reference Transcript
RefSeq:XM_017021246.1 FOXA1
RefSeq:NM_004496.3 FOXA1
Other Identifiers
11723333_at
11748971_a_at
3169
3561725
3561726
3561727
3561728
3561729
3561730
3561731
3561732
3561733
3561736
3561737
3561738
3561739
37141_at
7978706
A_23_P37127
A_24_P347431
A_33_P3332997
GE59130
GO:0000122
GO:0000278
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001650
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005902
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0007155
GO:0007219
GO:0007224
GO:0008134
GO:0009653
GO:0010468
GO:0010719
GO:0012501
GO:0019904
GO:0021904
GO:0022414
GO:0023052
GO:0030154
GO:0030182
GO:0030324
GO:0032355
GO:0033148
GO:0035239
GO:0042445
GO:0042593
GO:0043065
GO:0043226
GO:0043565
GO:0045880
GO:0045893
GO:0045931
GO:0045944
GO:0048646
GO:0048665
GO:0048856
GO:0051091
GO:0051726
GO:0060425
GO:0060441
GO:0060487
GO:0060528
GO:0060739
GO:0060740
GO:0060741
GO:0060743
GO:0061144
GO:0061448
GO:0071542
GO:0140110
GO:1902691
GO:1902895
GO:1904340
GO:1990837
GO:2000049
HMNXSV003002555
HMNXSV003005649
ILMN_1766650
PH_hs_0022768
TC14001056.hg
U39840_at
g4758533_3p_at
Participates
as a component of
ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] (Homo sapiens)
TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
TFF3 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
as an input of
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)
FOXA1 and GATA3 bind TFF genes (Homo sapiens)
FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
This entity regulates
Positively
Expression of NOTO in axial mesoderm
(Homo sapiens)
Expression of SHH in axial mesoderm
(Homo sapiens)
Inferred To
Foxa1 [nucleoplasm]
(Mus musculus)
Foxa1 [nucleoplasm]
(Rattus norvegicus)
FKH1 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of FOXA1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of FOXA1 [nucleoplasm]
(Xenopus tropicalis)
HCM1 [nucleoplasm]
(Saccharomyces cerevisiae)
sep1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of FOXA1 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of FOXA1 [nucleoplasm]
(Schizosaccharomyces pombe)
fkh [nucleoplasm]
(Drosophila melanogaster)
mei4 [nucleoplasm]
(Schizosaccharomyces pombe)
FOXA1 [nucleoplasm]
(Bos taurus)
FOXA1 [nucleoplasm]
(Canis familiaris)
FOXA1 [nucleoplasm]
(Gallus gallus)
FOXA1 [nucleoplasm]
(Sus scrofa)
foxa1 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_004487.2
,
XP_016876735.1
OpenTargets
ENSG00000129514
GeneCards
P55317
HPA
ENSG00000129514-FOXA1
Ensembl
ENSG00000129514
,
ENSP00000250448
,
ENST00000250448
PRO
P55317
Pharos - Targets
P55317
PDB
7VOX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.713
4
UniProt:Q02809 PLOD1
1
PLOD1 [endoplasmic reticulum membrane]
(R-HSA-1981109)
0.643
4
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.532
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text