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TBXT [nucleoplasm]
Stable Identifier
R-HSA-452976
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
T, T (BRACHYURY), Brachyury protein, BRAC_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of MESP1 in cardiogenesis (Homo sapiens)
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Gastrulation (Homo sapiens)
Epithelial-Mesenchymal Transition (EMT) during gastrulation (Homo sapiens)
EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of SNAI1 during gastrulation (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Formation of axial mesoderm (Homo sapiens)
Expression of FOXA2 in the anterior primitive streak (Homo sapiens)
TEAD2,TEAD4:YAP1:FOXH1:p-SMAD2,3:TBXT:FOXA2 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of NOTO in axial mesoderm (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TEAD2,TEAD4:YAP1, TBXT, FOXH1, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TEAD2,TEAD4:YAP1:FOXH1:p-SMAD2,3:TBXT:FOXA2 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of FOXA2 in definitive endoderm (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of GATA4 in definitive endoderm (Homo sapiens)
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Expression of DLL1 in paraxial mesoderm (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of TBX6 in paraxial mesoderm (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Germ layer formation at gastrulation (Homo sapiens)
EOMES and TBXT bind the NANOG gene (Homo sapiens)
EOMES:TBXT:NANOG gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)
EOMES:TBXT:POU5F1 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
EOMES and TBXT bind the SOX2 gene (Homo sapiens)
EOMES:TBXT:SOX2 gene [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)
TBXT [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15178 TBXT
Gene Names
TBXT, T (Brachyury), T
Chain
chain:1-435
Reference Genes
BioGPS Gene:6862 TBXT
COSMIC (genes):TBXT TBXT
CTD Gene:6862 TBXT
dbSNP Gene:6862 TBXT
ENSEMBL:ENSG00000164458 TBXT
ENSEMBL_homo_sapiens_GENE:ENSG00000164458.10 TBXT
HGNC:11515 TBXT
KEGG Gene (Homo sapiens):6862 TBXT
Monarch:6862 TBXT
NCBI Gene:6862 TBXT
OMIM:601397 TBXT
UCSC:O15178 TBXT
Reference Transcript
RefSeq:NM_003181.3 TBXT
RefSeq:NM_001270484.1 TBXT
Other Identifiers
11740136_a_at
17025576
206524_PM_at
206524_at
2984501
2984502
2984503
2984505
2984506
2984507
2984508
2984509
2984510
2984511
2984513
2984514
2984515
2984517
2984518
34966_at
6862
8130703
A_24_P63642
A_33_P3709150
GE87897
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001707
GO:0001708
GO:0001756
GO:0003007
GO:0003677
GO:0003700
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0007498
GO:0008595
GO:0023052
GO:0030154
GO:0043226
GO:0043433
GO:0045893
GO:0045944
GO:0048856
GO:0060379
GO:0061629
GO:0090009
GO:0140110
GO:1990837
HMNXSV003043729
ILMN_1794551
ILMN_2120762
PH_hs_0024502
TC06002304.hg
g4507338_3p_at
Participates
as a component of
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:NANOG gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:POU5F1 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SOX2 gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
TEAD2,TEAD4:YAP1:FOXH1:p-SMAD2,3:TBXT:FOXA2 gene [nucleoplasm] (Homo sapiens)
as an input of
EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)
EOMES and TBXT bind the NANOG gene (Homo sapiens)
EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)
EOMES and TBXT bind the SOX2 gene (Homo sapiens)
SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)
TEAD2,TEAD4:YAP1, TBXT, FOXH1, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
as an output of
Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)
This entity regulates
Positively
Expression of NOTO in axial mesoderm
(Homo sapiens)
Expression of DLL1 in paraxial mesoderm
(Homo sapiens)
Expression of TBX6 in paraxial mesoderm
(Homo sapiens)
Cross References
RefSeq
NP_001257413.1
,
NP_003172.1
OpenTargets
ENSG00000164458
HPA
ENSG00000164458-TBXT
GeneCards
O15178
Ensembl
ENST00000296946
,
ENSG00000164458
,
ENST00000366871
,
ENSP00000296946
,
ENSP00000355836
PRO
O15178
Pharos - Targets
O15178
PDB
5QS1
,
5QRG
,
6F59
,
5QSJ
,
5QSI
,
5QS0
,
5QS4
,
5QRS
,
5QSD
,
5QRT
,
5QSC
,
5QRI
,
8A10
,
5QRH
,
5QRL
,
5QRV
,
5QS7
,
8FMU
,
5QSF
,
5QS6
,
7ZK2
,
5QRU
,
5QSE
,
5QRK
,
7ZKF
,
5QRN
,
6ZU8
,
5QRM
,
7ZL2
,
5QSA
,
5QSK
,
5QRQ
,
5QRO
,
5QRZ
,
5QRF
,
5QRP
,
5QRY
,
5QT0
,
5QS3
,
5QRR
,
8CDN
,
5QS2
,
5QSB
,
5QSL
,
8A7N
,
5QS5
,
5QRJ
,
5QS9
,
6F58
,
5QRX
,
5QSH
,
5QRW
,
5QS8
,
5QSG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00712 NFIB
1
NFIB [nucleoplasm]
(R-HSA-60136)
0.471
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
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