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FRAT2 [cytosol]
Stable Identifier
R-HSA-452957
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GSK-3-binding protein FRAT2, FRAT2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT2 [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT2 [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT2 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
FRAT proteins bind GSK3beta (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT2 [cytosol] (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75474 FRAT2
Gene Names
FRAT2
Chain
chain:1-233
Reference Genes
BioGPS Gene:23401 FRAT2
COSMIC (genes):FRAT2 FRAT2
CTD Gene:23401 FRAT2
dbSNP Gene:23401 FRAT2
ENSEMBL:ENSG00000181274 FRAT2
ENSEMBL_homo_sapiens_GENE:ENSG00000181274.7 FRAT2
HGNC:16048 FRAT2
KEGG Gene (Homo sapiens):23401 FRAT2
Monarch:23401 FRAT2
NCBI Gene:23401 FRAT2
OMIM:605006 FRAT2
UCSC:O75474 FRAT2
Reference Transcript
RefSeq:NM_012083.2 FRAT2
Other Identifiers
11725518_at
16717102
209864_PM_at
209864_at
23401
3259791
3302230
3302231
3302232
3302233
3302234
3302235
40171_at
40172_g_at
7935421
88776_at
A_23_P12784
GE54579
GO:0003674
GO:0005575
GO:0005634
GO:0005737
GO:0005829
GO:0006886
GO:0006913
GO:0016055
GO:0023052
GO:0043226
GO:0046825
GO:1904886
HMNXSV003036109
ILMN_1788213
PH_hs_0008353
TC10001562.hg
g13365650_3p_at
Participates
as a member of
FRAT1,2 [cytosol] (Homo sapiens)
Inferred To
Frat2 [cytosol]
(Mus musculus)
Frat2 [cytosol]
(Rattus norvegicus)
FRAT2 [cytosol]
(Bos taurus)
FRAT2 [cytosol]
(Canis familiaris)
FRAT2 [cytosol]
(Gallus gallus)
FRAT2 [cytosol]
(Sus scrofa)
frat1 [cytosol]
(Xenopus tropicalis)
gbp [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_036215.1
OpenTargets
ENSG00000181274
GeneCards
O75474
HPA
ENSG00000181274-FRAT2
Ensembl
ENSP00000360058
,
ENST00000371019
,
ENSG00000181274
PRO
O75474
Pharos - Targets
O75474
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.527
3
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