Expression of SOX2

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SOX2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Rao et al. 2004, Richards et al. 2004). SOX2 protein is expressed in the cytoplasm of oocytes and day-2 cleavage-stage embryos and in the nuclei of all cells of the inner cell mass of blastocysts (Cauffman et al. 2009). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the SOX2 gene and enhance transcription (Chew et al. 2005, Boyer et al. 2005, Babaie et al. 2007, Assou et al. 2007, Greber et al. 2007). POU5F1 and SOX2 bind adjacent sites at the promoter and form a heterodimer on the DNA (Boyer et al. 2005). Hypoxia acts via HIF3A and EPAS1 (HIF2A) to activate expression of SOX2 (Forristal et al. 2010).

Literature References
PubMed ID Title Journal Year
14688391 The transcriptome profile of human embryonic stem cells as defined by SAGE

Richards, M, Bongso, A, Tan, SP, Chan, WK, Tan, JH

Stem Cells 2004
18824471 Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos

Cauffman, G, Sermon, K, De Rycke, M, Van de Velde, H, Liebaers, I

Hum Reprod 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
15493035 Comparative transcriptional profiling of two human embryonic stem cell lines

Calhoun, JD, Stice, SL, Clark, JK, Rekaya, R, Rao, RR, Qin, X

Biotechnol Bioeng 2004
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Lehrach, H, Greber, B, Adjaye, J

BMC Dev. Biol. 2007
18035408 Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Tanabe, K, Ohnuki, M, Tomoda, K, Narita, M, Yamanaka, S, Ichisaka, T, Takahashi, K

Cell 2007
19755485 Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

Houghton, FD, Forristal, CE, Oreffo, RO, Wright, KL, Hanley, NA

Reproduction 2010
15988017 Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

Robson, P, Tam, WL, Ang, YS, Lim, B, Loh, YH, Ng, HH, Chen, X, Li, P, Zhang, W, Yeap, LS, Chew, JL

Mol Cell Biol 2005
17204602 A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas

Le Carrour, T, Hamamah, S, De Vos, J, Ström, S, Hovatta, O, Assou, S, Klein, B, Marty, S, Réme, T, Hugnot, JP, Gabelle, A, Gasca, S, Nadal, L, Tondeur, S, Pantesco, V

Stem Cells 2007
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
This event is regulated
Positively by