Expression of FOXD3

Stable Identifier
R-HSA-452750
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of FOXD3
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The Forkhead box protein D3 (FOXD3) gene is transcribed and translated to yield FOXD3 protein. FOXD3 is expressed in blastomeres of the inner cell mass (Galan et al. 2010, Arduini et al. 2012). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the FOXD3 gene and POU5F1 enhances transcription (Babaie et al. 2007, Kunarso et al. 2010). The binding site of POU5F1 is not adjacent to the binding site of SOX2 on the FOXD3 promoter (Boyer et al. 2005). FOXD3 is a molecular marker of stem cells (Calloni et al.2013) and a balance of FOXD3 expression is required to maintain pluripotency (Arduini and Brinvalou 2012, inferred from mouse in Liu and Labosky 2008).
Literature References
PubMed ID Title Journal Year
21049019 Functional genomics of 5- to 8-cell stage human embryos by blastomere single-cell cDNA analysis

Galán, A, Montaner, D, Póo, ME, Valbuena, D, Ruiz, V, Aguilar, C, Dopazo, J, Simón, C

PLoS One 2010
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
22887036 Modulation of FOXD3 activity in human embryonic stem cells directs pluripotency and paraxial mesoderm fates

Arduini, BL, Brivanlou, AH

Stem Cells 2012
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
18653770 Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3

Liu, Y, Labosky, PA

Stem Cells 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm] (Homo sapiens)
Active Unit
NANOG [nucleoplasm]
POU5F1 [nucleoplasm]
SOX2 [nucleoplasm]
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-01-16)
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