Expression of TDGF1 (CRIPTO)

Stable Identifier
Reaction [omitted]
Homo sapiens
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The TDGF1 (CRIPTO) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. TDGF1/CRIPTO is expressed in embryonic stem cells (Adewumi et al. 2007, Li et al. 2006, Assou et al. 2009). GCNF (NR6A1) binds to the promoter of the TDGF1 (CRIPTO) gene and downregulates expression of TDGF1 (CRIPTO) during differentiation (Hentschke et al. 2006). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the TDGF1 gene and enhance transcription (Babaie et al. 2007, Greber et al. 2007, Watanabe et al. 2010). SOX2 binds the TDGF1 promoter adjacent to POU5F1 (Boyer et al. 2005). TDGF1 is a marker of undifferentiated stem cells (reviewed in Bianco et al. 2010, de Castro et al. 2010). Expression of TDGF1 is associated with tumorigenesis (Ciardiello et al. 1991).
Literature References
PubMed ID Title Journal Year
1715580 Differential expression of epidermal growth factor-related proteins in human colorectal tumors

Kim, N, Garrigues, J, Persico, MG, Radke, S, Salomon, DS, Dono, R, Ciardiello, F, Todaro, GJ, Plowman, GD, Saeki, T

Proc Natl Acad Sci U S A 1991
16978057 Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan

Tseng, CN, Liu, YH, Li, SS, Lee, TY, Singh, S, Chung, TL

Stem Cells Dev 2006
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Lehrach, H, Greber, B, Adjaye, J

BMC Dev. Biol. 2007
17572666 Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

Ahrlund-Richter, L, Mallon, BS, Vuoristo, S, McKay, RD, Nakatsuji, N, Nagy, A, Blum, B, Mileikovsky, M, Gertow, K, Michalska, AE, Johnson, JL, Sherrer, ES, Mikkola, M, Benvenisty, N, O'Brien, CM, Olsson, C, Vintersten, K, Mummery, CL, Emanuelsson, K, Berry, LS, Ward, D, Siemen, H, Bello, PA, van den Brink, S, Patel, M, Brooking, J, Mayshar, Y, Robins, AJ, Gokhale, PJ, Ford, A, Pera, RA, Piekarczyk, MS, Szatkiewicz, J, Jones, M, International Stem Cell, Initiative, Gertsenstein, M, Fleck, RA, Lebrin, F, Corbel, M, Suemori, H, Semb, H, Dvorak, P, Knowles, BB, Moore, HD, Amit, M, Hyllner, J, Andrews, PW, Itskovitz-Eldor, J, Pera, MF, Zhang, W, King, BL, Rossant, J, Hovatta, O, Hamilton, RS, Imreh, MP, Schulz, TC, Draper, JS, Patel, H, Minger, SL, Reubinoff, BE, Chen, KG, Otonkoski, T, Lako, M, Tuuri, T, Passier, R, Weaver, TA, Pedersen, R, Damjanov, I, Park, KY, Hampl, A, Manning, D, Stacey, GN, Adewumi, O, Rugg-Gunn, P, Jackson, J, Choo, AB, Churchill, GA, Beighton, G, Healy, LE, Turetsky, T, Oh, SK, Bevan, S, Aflatoonian, B, Kee, K, Stojkovic, M, Young, LA

Nat Biotechnol 2007
20616345 Role of Cripto-1 in stem cell maintenance and malignant progression

Nagaoka, T, Salomon, DS, Rollman, K, Rangel, MC, Castro, NP, Bianco, C, Gonzales, M

Am. J. Pathol. 2010
19128516 A gene expression signature shared by human mature oocytes and embryonic stem cells

Hamamah, S, De Vos, J, Hovatta, O, Tondeur, S, Cerecedo, D, Assou, S, Klein, B, Pantesco, V

BMC Genomics 2009
20624125 Cripto-1: an embryonic gene that promotes tumorigenesis

Nagaoka, T, Salomon, DS, Rangel, MC, Bianco, C, de Castro, NP

Future Oncol 2010
20549704 Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells

Nagaoka, T, Lee, JM, Salomon, DS, Meyer, MJ, Watanabe, K, Farid, SS, Margaryan, N, Hendrix, MJ, Bianco, C, Vonderhaar, BK, Strizzi, L, Gonzales, M

Stem Cells 2010
16954206 Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3

Hübner, CA, Kurth, I, Hentschke, M, Borgmeyer, U

J Biol Chem 2006
17204602 A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas

Le Carrour, T, Hamamah, S, De Vos, J, Ström, S, Hovatta, O, Assou, S, Klein, B, Marty, S, Réme, T, Hugnot, JP, Gabelle, A, Gasca, S, Nadal, L, Tondeur, S, Pantesco, V

Stem Cells 2007
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
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