Reactome | Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

Stable Identifier

R-HSA-452108

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

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Mutation analysis has shown that Y338, Y392 and Y510 are involved in IL-2-induced STAT protein binding. Phospho-tyrosines 338, 392 and 510 can each promote STAT5 activation (Gaffen et al. 1996), though Y510 appears to be the primary site for STAT5 binding (Gesbert et al. 1998). STAT3 may also be recruited to phospho-tyrosines on IL2RB and studies have shown defective IL-2 responses in STAT3-/- T cells, thereby supporting a functional role for STAT3 downstream of IL-2 signaling (Akaishi et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
8631883	Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells Lin, JX, Mietz, J, Modi, WS, John, S, Leonard, WJ	J Biol Chem	1996
8702919	Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity Gaffen, SL, Lai, SY, Ha, M, Liu, X, Hennighausen, L, Greene, WC, Goldsmith, MA	J Biol Chem	1996